Key Takeaways
- The global size of the female hormone balance supplements market was valued at $4.5 Billion in 2023 and is expected to reach $8.50 Billion by 2032.
- Phytoestrogens weakly bind to estrogen receptors, fooling the body into thinking and reacting as though there is more estrogen present, thereby reducing some menopausal symptoms
- In women, many nutraceuticals have been shown to help promote hormone balance, including Shatavari, probiotics, inositol, magnesium, omega-3 fatty acids, vitamin D, Ashwagandha, Chasteberry, and B vitamins
- In choosing the right female hormone balance supplement, it is important to consider delivery form, ingredients, quality and purity, and certifications.
Many women incorporate female hormone balance supplements into their wellness routines to support healthy hormonal function across various life stages. Areas of focus commonly include supporting the body during the menstrual and premenstrual cycle, as well as maintaining balance during the menopausal transition.
Reflecting this growing demand, the global market for female hormone balance supplements was valued at approximately $4.5 billion in 2023 and is projected to reach $8.5 billion by 2032, representing a compound annual growth rate (CAGR) of 7.6%.1Women’s Hormonal Supplements Market Size Worth US$ 8.50 Billion By 2032, Increasing Awareness of Women’s Health and Wellness Drives Growth | Research by SNS Insider. yahoo!finance. August 13, 2024. Retrieved December 16, 2025 from https://finance.yahoo.com/news/women-hormonal-supplements-market-size-133100547.html?guccounter=1&guce_referrer=aHR0cHM6Ly93d3cuZ29vZ2xlLmNvbS8&guce_referrer_sig=AQAAAL53heKrUPFMTukpspfl3Q2HtZIbm6oNSXnIFDAYh_ZHsJoeVjoQd09L1L-rcWaJOFJhhsFqUJ5Bmof9HR-Ye5h_Y5r8JS7fGlWYWZSao403FwYfNLXTaimll3hxTTPBVth-mZRYDYVj6A5zJQoqwKOxK-zvdM3NTrBvrNwlvn9k.
In this article, we examine key ingredients commonly used in women’s hormone support formulations and outline important considerations for selecting a compliant, well-positioned supplement.
Best Female Hormone Balance Supplements
Natural supplements for female hormone balance generally fall into two primary categories. The first includes ingredients that may weakly interact with estrogen receptors in the body; these compounds are commonly referred to as phytoestrogens. The second category consists of nutraceutical ingredients that support hormonal balance through pathways not directly associated with hormone receptor binding.
In the following section, we’ll begin by exploring phytoestrogens and their role in female hormone balance supplement formulations.
Phytoestrogens
Phytoestrogens are naturally occurring plant compounds that may weakly bind to estrogen receptors in the body. While phytoestrogens are not the same as endogenous estrogen, their ability to interact with estrogen receptors allows them to mimic certain estrogen-like activities, which may help support hormonal balance during specific life stages.
Common phytoestrogen ingredients used in female hormone balance supplements include:
- Hops cone extract – Contains the phytoestrogen, 8-prenylnaringenin. In human studies, hops cone extract was shown to exert favorable effects on hot flashes and other menopausal discomforts.2Erkkola R, Vervarcke S, Vansteelandt S, Rompotti P, De Keukeleire D, Heyerick A. A randomized, double-blind, placebo-controlled, cross-over pilot study on the use of a standardized hop extract to alleviate menopausal discomforts. Phytomedicine. 2010 May;17(6):389-96. 3Heyerick A, Vervarcke S, Depypere H, Bracke M, De Keukeleire D. A first prospective, randomized, double-blind, placebo-controlled study on the use of a standardized hop extract to alleviate menopausal discomforts. Maturitas. 2006 May 20;54(2):164-75.
- Soy isoflavones – These phytoestrogens may be helpful for relieving hot flashes and night sweats4National Cancer Institute: Cancer Facts “Menopausal Hormone Replacement Therapy” http://cis.nci.nih.gov/fact/3_10.htm, as well as supporting bone density.5Scheiber MD, Rebar RW, Menopause (1999) 6(3):233-41.
- Rhapontic rhubarb (Siberian rhubarb) extract – A phytoestrogen that has been studied for its ability to support relief from menopause-related night sweats and promote a healthy mood during menopause.6Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, Heger PW. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006 Sep-Oct;13(5):744-59. 7Kaszkin-Bettag M, Ventskovskiy BM, Solskyy S, Beck S, Hasper I, Kravchenko A, Rettenberger R, Richardson A, Heger PW. Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms. Altern Ther Health Med. 2009 Jan-Feb;15(1):24-34.
- Pueraria mirifica extract – This phytoestrogenic herb has demonstrated effectiveness in reducing hot flashes, night sweats, and reducing occasional, menopause-related nervousness.8Virojchaiwong P, Suvithayasiri V, Itharat A. Comparison of Pueraria mirifica 25 and 50 mg for menopausal symptoms. Arch Gynecol Obstet. 2011 Aug;284(2):411-9. 9Lamlertkittikul S, Chandeying V. Efficacy and safety of Pueraria mirifica (Kwao Kruea Khao) for the treatment of vasomotor symptoms in perimenopausal women: Phase II Study. J Med Assoc Thai. 2004 Jan;87(1):33-40. 10Chandeying V, Lamlertkittikul S. Challenges in the Conduct of Thai Herbal Scientific Study: Efficacy and Safety of Phytoestrogen, Pueraria Mirifica (Kwao Keur Kao), Phase I, in the Alleviation of Climacteric Symptoms in Perimenopausal Women. J Med Assoc Thai 2007; 90 (7):1274-80. 11Manonai J, Chittacharoen A, Theppisai U, Theppisai H. Effect of Pueraria mirifica on vaginal health. Menopause. 2007 Sep-Oct;14(5):919-24.
In the next section, we’ll explore additional ingredient categories commonly used in supplements for female hormone balance.
Shatavari
Shatavari (Asparagus racemosus) is an Ayurvedic botanical traditionally used to support female hormonal health. Human research12Mahajan S, Avad P, Langade J. Efficacy and Safety of Shatavari (Asparagus racemosus) Root Extract for Perimenopause: Randomized, Double-Blind, Placebo-Controlled Study. Int J Womens Health. 2025 Nov 3;17:4057-4073. doi: 10.2147/IJWH.S544267. PMID: 41209045; PMCID: PMC12593836. indicates it may help relieve menopausal symptoms, such as hot flashes, while improving fatigue and vigor, and relieving occasional stress. Additional findings indicate Shatavari may help maintain healthy levels of estradiol, follicle-stimulating hormone (FSH), and thyroid hormone activity.13Alok S, Jain SK, Verma A, Kumar M, Mahor A, Sabharwal M. Plant profile, phytochemistry and pharmacology of Asparagus racemosus (Shatavari): A review. Asian Pac J Trop Dis. 2013 Jun;3(3):242–51. doi: 10.1016/S2222-1808(13)60049-3. PMCID: PMC4027291.
Probiotics
Research14Honda S, Tominaga Y, Espadaler-Mazo J, Huedo P, Aguiló M, Perez M, Ueda T, Sawashita J. Supplementation with a Probiotic Formula Having β-Glucuronidase Activity Modulates Serum Estrogen Levels in Healthy Peri- and Postmenopausal Women. J Med Food. 2024 Aug;27(8):720-727. doi: 10.1089/jmf.2023.k.0320. Epub 2024 Jun 16. PMID: 38742994. has shown that probiotics containing strains with β-glucuronidase activity (e.g., Levilactobacillus brevis KABP052) helped maintain serum estrogen levels in healthy peri- and postmenopausal women, providing direct human evidence that probiotics can modulate systemic estrogen levels via gut microbial activity.
Additional population research15Zou S, Yang X, Li N, Wang H, Gui J, Li J. Association of probiotic ingestion with serum sex steroid hormones among pre- and postmenopausal women from the NHANES, 2013-2016. PLoS One. 2023 Nov 16;18(11):e0294436. doi: 10.1371/journal.pone.0294436. PMID: 37972004; PMCID: PMC10653486. found that women who report consuming yogurt or probiotic supplements had higher estrogen levels during pre-menopause and lower total testosterone levels during post menopause compared with women who do not consume probiotics.
Inositol
Human research16Gerli S, Mignosa M, Di Renzo GC. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur Rev Med Pharmacol Sci. 2003 Nov-Dec;7(6):151-9. PMID: 15206484. has found that inositol supplementation supports ovulation frequency and reduces time to first ovulation compared with placebo, suggesting a role in supporting ovarian hormonal function. Other research17Pustotina O, Myers SH, Unfer V, Rasulova I. The Effects of Myo-Inositol and D-Chiro-Inositol in a Ratio 40:1 on Hormonal and Metabolic Profile in Women with Polycystic Ovary Syndrome Classified as Phenotype A by the Rotterdam Criteria and EMS-Type 1 by the EGOI Criteria. Gynecol Obstet Invest. 2024;89(2):131-139. doi: 10.1159/000536163. Epub 2024 Jan 31. PMID: 38295772; PMCID: PMC11126204. has shown that inositol supplementation may help maintain healthy estrogen levels and overall hormonal balance in women.
Magnesium
Research18Jamilian M, Mirhosseini N, Rahimi F, Asemi Z. The effects of magnesium plus vitamin E or zinc supplementation on reproductive hormones in women with PCOS: a randomized controlled trial. J Obstet Gynaecol Res. 2017;43(12):1845-1853. in women has shown that magnesium supplementation helps promote a healthy balance of reproductive hormones. Magnesium also plays a role in insulin signaling, which is closely linked to sex hormone regulation.19Guerrero-Rodriguez FM, et al. Effect of magnesium supplementation on glucose metabolism: a meta-analysis. Eur J Clin Nutr. 2020. Furthermore, magnesium supplementation alone or with vitamin B6 reduced premenstrual symptoms, including mood-related and physical discomforts, likely due to magnesium’s influence on neurotransmitter pathways and steroid hormone synthesis/metabolism.20Facchinetti F, et al. Magnesium and vitamin B6, alone or in combination, in the treatment of premenstrual syndrome: a randomized, placebo-controlled study. Obstet Gynecol. 1991;77(1):29–36.
Omega-3 Fatty Acids
Human research21Watson H, Mitra S, Croden FC, et al. A randomised trial of the effect of omega-3 polyunsaturated fatty acid supplements on the human intestinal microbiota. Gut. 2018;67(11):1974–1983. doi:10.1136/gutjnl-2017-314968 indicates that omega-3 supplementation can influence gut microbiota composition, supporting short-chain fatty acid (SCFA) production and enzymatic activity relevant to estrogen recycling. Population-based human data22Gaskins AJ, Mumford SL, Zhang C, et al. Effect of daily fiber intake on reproductive function: the BioCycle Study. American Journal of Clinical Nutrition. 2013;98(2):462–470. doi:10.3945/ajcn.112.056770 have also linked omega-3 fatty acid intake or status with estrogen concentrations. Additionally, clinical trials23Cussons AJ, Watts GF, Mori TA, Stuckey BGA. Omega-3 fatty acid supplementation decreases liver fat content and improves metabolic and inflammatory markers in women with polycystic ovary syndrome. American Journal of Clinical Nutrition. 2009;90(4):970–976. doi:10.3945/ajcn.2009.27938 in women show omega-3s improve outcomes influenced by estrogen signaling by reducing menstrual discomfort, improving metabolic profiles, and menopausal symptom burden.
Vitamin D
Vitamin D supplementation has been shown to promote menstrual regularity and healthy levels of luteinizing hormone in women.24Han Y, Cao Q, Qiao X, Huang W. Effect of vitamin D supplementation on hormones and menstrual cycle regularization in polycystic ovary syndrome women: A systemic review and meta-analysis. J Obstet Gynaecol Res. 2023 Sep;49(9):2232-2244. doi: 10.1111/jog.15727. Epub 2023 Jun 26. PMID: 37364886. Vitamin D status is also associated with reproductive hormone balance and menopausal comfort.25Muho KH. Impact of Vitamin D status on age at menopause: A prospective cohort study. J Adv Pharm Technol Res. 2025 Oct-Dec;16(4):190-194. doi: 10.4103/JAPTR.JAPTR_52_25. Epub 2025 Oct 20. PMID: 41234345; PMCID: PMC12610294. Beyond this, vitamin D plays a direct role in female reproductive hormone synthesis and ovarian function.26van Tienhoven XA, Ruiz de Chávez Gascón J, Cano-Herrera G, Sarkis Nehme JA, Souroujon Torun AA, Bautista Gonzalez MF, Esparza Salazar F, Sierra Brozon A, Rivera Rosas EG, Carbajal Ocampo D, Cabrera Carranco R. Vitamin D in Reproductive Health Disorders: A Narrative Review Focusing on Infertility, Endometriosis, and Polycystic Ovarian Syndrome. Int J Mol Sci. 2025 Mar 3;26(5):2256. doi: 10.3390/ijms26052256. PMID: 40076878; PMCID: PMC11899835.
Ashwagandha
Among peri-menopausal women, supplementation with Ashwagandha root extract significantly improved menopause-related symptoms and was associated with increases in serum estradiol and decreases in follicle-stimulating hormone (FSH) and luteinizing hormone (LH) compared with placebo, suggesting support for hormonal balance during the menopausal transition.27Gopal S, Ajgaonkar A, Kanchi P, Kaundinya A, Thakare V, Chauhan S, Langade D. Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause: A randomized, double-blind, placebo-controlled study. J Obstet Gynaecol Res. 2021 Dec;47(12):4414-4425. doi: 10.1111/jog.15030. Epub 2021 Sep 22. PMID: 34553463. Additional research has shown that Ashwagandha root extract supports female sexual function in healthy adult women.28Ajgaonkar A, Jain M, Debnath K. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract for Improvement of Sexual Health in Healthy Women: A Prospective, Randomized, Placebo-Controlled Study. Cureus. 2022 Oct 28;14(10):e30787. doi: 10.7759/cureus.30787. PMID: 36447681; PMCID: PMC9701317.
Chasteberry
Research has shown that Chasteberry (Vitex angus-castus) supports the increase of progesterone levels.29Blumenthal M, Hall T, Goldberg A, Kunz T, Dinda K, Brinckmann J, et al, eds. The ABC Clinical Guide to Herbs. Austin, TX: American Botanical Council; 2003. Studies have shown that using Chasteberry once in the morning over a period of several months helps promote hormone balance to reduce premenstrual symptoms.30Dittmar FW, et al, Therapiwoche Gynäkol (1992) 5:60B68. Chasteberry is also widely recognized for its role in supporting normal ovulation and menstrual regularity, including approval for these uses by Germany’s Commission E monographs.31Blumenthal M, Goldberg A, Brinckmann J (eds.). Herbal Medicine: Expanded Commission E Monographs (2000) Integrative Medicine Communications; Newton, Massachusetts. Pp. 62-64. As a botanical that works gradually, it is typically recommended for use over at least three menstrual cycles to evaluate individual response.
B Vitamins
Research32Kim K, Mills JL, Michels KA, et al. Dietary intakes of vitamins B2, B6, and B12 and ovarian cycle function among premenopausal women. J Acad Nutr Diet. 2019;120(5):885–892. examining dietary intake of vitamins B2 (riboflavin), B6, and B12 has identified associations with reproductive hormone markers in healthy premenopausal women. Higher riboflavin intake was linked to modest reductions in serum estrogen, while higher B6 intake showed trends toward increased follicle-stimulating hormone (FSH). Vitamins B2 and B12 were also associated with lower homocysteine levels, which are relevant to hormone metabolism. Supplementation with vitamin B6, B12, and folate (along with vitamin C) promoted healthy estrogen levels in overweight postmenopausal women, suggesting B-vitamin involvement in estrogen metabolism in women beyond reproductive age.33Palmas W. Effects of short-term supplementation with ascorbate, folate, and vitamins B6 and B12 on inflammatory factors and estrogen levels in obese postmenopausal women. Int J Vitam Nutr Res. 2006 Jan;76(1):34-8. doi: 10.1024/0300-9831.76.1.34. PMID: 16711655.
Expert Tips for Creating a Female Hormone Balance Supplement
Creating an effective hormone support supplement requires brand owners to carefully evaluate several strategic factors, including delivery format, ingredient selection, quality standards, and manufacturing credentials. Taking a disciplined, science-informed approach to these considerations helps ensure the finished product aligns with consumer expectations, regulatory requirements, and long-term brand positioning in a competitive category.
Select the Right Format for Your Needs
Choosing the right delivery format for your product is a good place to start when developing a hormone support supplement. Capsules and tablets are widely accepted formats for many consumers; however, brands should also consider alternative formats for individuals who prefer not to swallow solid dosage forms. Powdered supplements, for example, offer added flexibility by allowing consumers to mix the product into a beverage of their choice, which can be particularly appealing for brands already offering powdered formats such as collagen.
Ultimately, format selection should align with consumer preferences, usage occasions, and overall product positioning.
Consider Key Ingredients for Hormonal Health
When selecting ingredients for a hormone support formulation, brand owners should begin by clearly defining the target consumer and life stage the product is intended to support. For formulations positioned toward menopausal support, commonly used ingredients (as covered previously in this article) include phytoestrogens, Shatavari, probiotics, omega-3 fatty acids, vitamin D, Ashwagandha, and B vitamins.
For products designed to support premenopausal or premenstrual wellness, ingredients such as inositol, magnesium, omega-3 fatty acids, vitamin D, Ashwagandha, Chasteberry, and B vitamins (also discussed in this article) are frequently incorporated to help support normal hormonal function.
Look for Quality and Purity
Quality and purity should be central considerations when developing a hormone support supplement. Brand owners should evaluate their supplement manufacturers’ ingredient sourcing practices, including whether raw materials are non-GMO, responsibly sourced, and aligned with clean-label expectations. Additionally, the use of trademarked ingredients can indicate a higher level of formulation rigor, as these ingredients are often supported by ingredient-specific research and quality controls that help promote consistency and reliability in the finished product.
Check for Certifications and Third-Party Testing
Lastly, supplement quality certifications and third-party testing serve as critical indicators of a manufacturer’s commitment to quality, compliance, and operational integrity. Brand owners should confirm that their supplements are being produced in facilities that follow Good Manufacturing Practices (GMP). Beyond internal quality controls, reputable manufacturers often utilize independent third-party testing to help verify product identity, potency, and safety.
Conclusion
This article explained the key considerations involved in developing effective female hormonal balance supplements, from understanding ingredient categories and life-stage applications to selecting appropriate formats and maintaining quality standards. For brand owners, the central takeaway is that successful product development requires a strategic, science-informed approach that balances consumer demand, regulatory compliance, and long-term brand positioning. Ingredient selection, sourcing transparency, GMP manufacturing, and third-party testing all play a critical role in delivering products that meet market expectations while supporting label integrity and consistency.
As you move from concept to commercialization, choosing the right herbal supplements manufacturer becomes a pivotal decision. Working with an experienced manufacturer of herbal supplements can help you navigate formulation complexity, regulatory requirements, and quality assurance protocols with confidence. Equally important is partnering with a trusted herbal supplement manufacturer in the USA that offers turnkey manufacturing, robust quality systems, and deep category expertise.
If you’re evaluating partners to bring your next women’s health product to market, Vitaquest combines decades of industry experience with comprehensive formulation, manufacturing, and compliance support.
Contact us to discuss how we can help you develop high-quality hormone support supplements with confidence. Call 800-526-9095 to speak with one of our knowledgeable production specialists or request a nutraceutical manufacturing price quote if you’ve already finalized your project requirements.
Frequently Asked Questions About Female Hormonal Balance Supplements
Which multivitamin is best for hormonal imbalance?
If you’re looking for a multivitamin to promote hormone balance in women, choose one that includes vitamin D, B vitamins, and magnesium, since each has a biological role in supporting female hormonal health. In addition, you may consider including other ingredients shown to have hormonal support value, such as Shatavari, probiotics, inositol, omega-3 fatty acids, Ashwagandha, and Chasteberry.
