Exploring the Supplement Trends for 2026

By Lauren
Samot, RD
07/07/2025
Annual Manufacturing Trends, Beauty From Within, Blog, Bone & Joint Health, Brain Health & Sleep, Capsules, Cold/Flu/Immunity, GI Health, Heart Health, Manufacturing Solutions, Metabolic Health, Powders, Probiotics, Sports/Energy/Exercise, Tablets, Women's General Health

2026 is shaping up to be a landmark year for supplement innovation. See which trends are set to dominate—and how to stay ahead of the curve with your brand!

Supplement industry statistics have shown that the global dietary supplements market was valued at $192.65 billion in 2024 and is projected to reach $327.42 billion by 2030, reflecting a compound annual growth rate (CAGR) of 9.1%.

This growth is driven by multiple converging factors: the rising prevalence of chronic health conditions such as obesity, diabetes, and cardiovascular disease; and increasingly fast-paced lifestyles, which continue to alter global dietary habits and fuel demand for convenient, health-supportive solutions.¹

According to online supplement sales statistics from Nutraceuticals World’s analysis of NBJ data², the top markets in the U.S. dietary supplement industry by ingredient category were:

Vitamins 27.5%
Specialty ingredients 21.8%
Herbs and botanicals 19.2%
Sports nutrition 15.2%
Meal replacements 10.3%
Minerals 5.9%

The sports nutrition supplement category is leading in growth, with an 8.4% year-over-year increase. This segment alone is projected to contribute an additional $3.86 billion in value by 2028, underscoring its importance as a key driver in the future of the supplement industry.

Sales of specialty supplements rose by approximately 6.3%, driven by growing consumer demand for ingredients such as collagen, fiber, and pre-, pro-, and synbiotics. This segment is projected to contribute an additional $4.71 billion in value by 2028. Other notable category gains include a 5.7% increase in meal replacements, 5.4% in herbs and botanicals, 4.1% in minerals, and 2.7% in vitamins.

Taken together, these figures highlight key areas of momentum within the dietary supplement space heading into 2026. This blog article will explore these supplement trends, including plant-based protein supplements, nootropic supplements, gut health supplements, performance & recovery supplements, creatine, nitric oxide supplements, shilajit, gaming supplements, herbal supplements, and hydration supplements.

Trending Supplement Categories in 2026

Plant-Based Protein Supplements

The global plant-based protein market was valued at $14.3 billion in 2024 and is projected to reach $20.5 billion by 2029, with a CAGR of 7.5%.³

Several key factors are driving this growth. First, plant-based proteins are an ideal option for vegans and vegetarians seeking alternatives to animal-derived proteins such as whey and casein. Second, sustainability is a significant motivator, as plant-based proteins generally have a lower environmental impact. Lastly, these proteins offer low allergenic potential, making them accessible to individuals with sensitivities to dairy or other common allergens.

The most common sources of plant-based protein in supplements include peas and rice.

Pea Protein

Pea protein is well known for its high protein content and excellent digestibility.⁴ Clinical studies show that pea protein isolate can effectively reduce food intake⁵ when consumed at the beginning of a meal, outperforming whey and egg white proteins in this regard.⁶ ⁷ In addition, research⁸ demonstrated that pea protein promoted diet-induced thermogenesis (fat burning). Research⁹ also demonstrated that pea protein helped maintain healthy blood pressure levels already within normal ranges more significantly than consuming a placebo. In animal studies¹⁰, pea protein also showed strong anti-fatigue effects, decreased lactic acid, increased muscle and liver glycogen, improved insulin levels, and had strong antioxidant and immune activity.

In the past, pea protein’s popularity was hindered by its earthy or bitter taste. However, recent advances in flavor-masking technologies and extraction methods have significantly improved its organoleptic profile. Through enzymatic processing, microencapsulation, and natural masking agents, pea protein powder manufacturers can now greatly reduce the off-notes traditionally associated with pea protein, making it a more viable option for flavored powders, ready-to-drink beverages, and functional foods.

Rice Protein

Rice protein is considered to be hypoallergenic¹¹, and provides approximately 78% protein by weight, including 36% essential amino acids and 18% branched-chain amino acids (BCAAs).¹² Research shows rice protein isolate can support reductions in fat mass while increasing lean body mass, skeletal muscle hypertrophy, power, and strength—with outcomes comparable to whey protein isolate.¹³ In a comparative study¹⁴, rice protein demonstrated similar effects on body weight and fat-free mass as whey, with a slight advantage in reducing body fat, although not statistically significant.

Nootropic Supplements

Nootropic supplements, formulated to enhance memory, focus, and overall cognitive performance, continue to gain momentum in the health and wellness space. The global nootropic supplement market was valued at $2.3 billion in 2024 and is projected to grow to $5 billion by 2034, with a CAGR of 7.8% from 2025 through 2034.¹⁵

This category encompasses a wide range of nutraceutical compounds, many of which are backed by strong scientific evidence supporting their cognitive benefits. Among the most well-researched and widely used nootropics are Rhodiola rosea, Bacopa monnieri, and Lion’s Mane mushroom. Each offers distinct mechanisms to support mental clarity, memory, stress resilience, and neurological health.

Rhodiola

Rhodiola rosea is a well-established adaptogen, a class of substances, often herbal in origin, that help the body maintain balance and adapt to physical, emotional, and environmental stressors. While adaptogens generally do not exert a specific pharmacological action, they are known to support homeostasis and overall resilience.

Used for centuries in traditional medicine systems across Russia, Scandinavia, and other regions, Rhodiola rosea has a long history of supporting both mental and physical well-being.¹⁶ Modern research has confirmed its ability to enhance cognitive function under stress, improve mental performance, and increase physical endurance. Clinical studies also suggest that Rhodiola may help reduce fatigue, boost mood, enhance work productivity, and even support aspects of sexual health, particularly in individuals experiencing stress-related declines in performance.¹⁷ ¹⁸ ¹⁹

Bacopa

The leaves of the Bacopa monnieri plant have been used for centuries in the traditional East Indian system of healthcare (Ayurveda) for purposes of promoting “healthy longevity, and strengthening life, brain, and mind.”²⁰

Modern clinical studies²¹ ²² ²³ ²⁴ ²⁵ ²⁶ ²⁷ have shown that daily supplementation with Bacopa monnieri leaf extract helped improve occasional, age-related absentmindedness, promoted a healthy memory, improved some measures of delayed recall, and promoted cognitive function. Research²⁸ suggests that Bacopa works by helping to maintain healthy levels of acetylcholine, a compound the body makes to help the brain facilitate memory, learning ability and cognitive performance.

Lion’s Mane Mushroom

Lion’s mane (Hericium erinaceus) is a functional mushroom traditionally used to support immune health and provide antioxidant protection against oxidative stress caused by free radicals.²⁹ In recent years, it has gained significant attention for its potential cognitive benefits.³⁰ ³¹

One randomized, double-blind, placebo-controlled study showed that it improved cognitive function, while another showed that participants taking Lion’s mane scored significantly higher on cognitive function tests compared to the placebo group. In addition, research demonstrated that Lion’s mane may help reduce moodiness.³²

Postbiotics

Postbiotics (any probiotic that has been pasteurized or heat-treated, and yet still provides health benefits—a sort of zombie probiotic) are gaining popularity. The postbiotic supplements market is estimated to be valued at $10.8 million in 2024 and expected to reach $30.5 million by 2034 at a CAGR of 10.9%.³³ Since they’re no longer alive, postbiotics have the advantage since there is no concern for stability as is the case with probiotics. Consequently, they can easily be used in virtually any delivery form and combined with any other nutraceutical. Two examples of postbiotics with research to support their efficacy include:

Lactobacillus plantarum strain L-137 (ImmunoLP20®) has been shown to augment acquired immunity³⁴ (especially Th1-related immune functions in healthy subjects), support the function of an influenza vaccine³⁵, support upper respiratory health³⁶, and help reduce inflammatory markers.³⁷
Akkermansium mucinipahila has been shown to support metabolic health, helps activate GLP-1 inducing protein, help decrease body weight, help decrease hip and waist size.³⁸

GLP-1 Stimulants/Complements

Anyone who attended Natural Products Expo West in March of 2025, or VitaFoods in May of 2025, won’t be surprised that nutraceuticals with claims to stimulate the production of GLP-1 were seriously trending. Booths offering such nutraceuticals were all over the place. It should be noted that nutraceuticals that stimulate GLP-1 production aren’t the same as, and won’t have similar efficacy for appetite suppression, as drugs that are GLP-1 agonists (i.e., bind to GLP-1 receptors). Nevertheless, many of these nutraceuticals may still offer other benefits for weight loss. Furthermore, there is a range of nutraceuticals that aren’t GLP-1 stimulants but may also function in a complementary way with GLP-1 agonist drugs. Consider the following:

Akkermansium mucinipahila – As stated in the previous section, Akkermansium mucinipahila is a GLP-1 that helps with weight loss, but not necessarily appetite suppression.
Collagen – Sagging skin can occur alongside rapid weight loss, such as occurs with the use of GLP-1 agonist drugs. As a structural protein, it is ideal for combating saggy skin. Collagen peptides have been shown³⁹ to support and stimulate the body’s own collagen production and skin elasticity.
Creatine – Maintaining lean muscle during rapid weight loss can be a challenge. Creatine serves as an anabolic signal for muscle growth, acting as the chemical messenger that links increased muscle activity with the production of new muscle tissue.⁴⁰ ⁴¹

Women’s Health (Urinary Health, Menopause, Fertility)

The global women’s health and beauty supplements market generated a revenue of $57.4 billion in 2024 and is expected to reach $77.5 billion by 2030.⁴² Specific areas of interest within this category are urinary health, menopause, and fertility.

Urinary Health

Simply due to internal plumbing differences, women tend to have more concerns about urinary tract health than men and so represent a major part of the urinary health supplement market, which was estimated at $1.77 billion in 2023 and expected to grow to $3.04 billion by 2030.⁴³ A few good nutraceuticals with particularly good research for promoting urinary tract health include:

Cranberry extract – Cranberry extract has been clinically tested to promote and maintain urinary tract health in women. This is particularly true of those providing at least 72 mg of PACs, the active components in cranberry.⁴⁴ ⁴⁵ ⁴⁶
Centaury (aerial parts, Lovage (root), and Rosemary (leaves) – In human clinical research, a combination of these herbs was shown to have good results in maintaining lower urinary tract health in women ranging in age between 18-70 years.⁴⁷ ⁴⁸ ⁴⁹
Lactobacillus rhamnosus GR-1® and Lactobacillus reuteri RC-14® – The combination of these probiotics has been clinically studied to promote urinary tract health in women, as well as supporting a balance of healthy bacteria in women’s urinary tracts and supporting vaginal health.⁵⁰ ⁵¹ ⁵² ⁵³

Menopause

With the aging of America⁵⁴, roughly 2 million women per year are starting menopause.⁵⁵ Consequently, natural remedies for menopause are becoming increasingly popular. While there are many menopause support nutraceuticals from which to choose, three especially good ones include:

Rheum rhaponticum L. root extract (Siberian Rhubarb) – In clinical research, Siberian Rhubarb helped relieve hot flashes by 60-90% in 12 weeks. It also helped relieve menopause-related night sweats while promoting vaginal comfort and healthy sexual function in menopausal women.⁵⁶ ⁵⁷ ⁵⁸ ⁵⁹ ⁶⁰
Black Cohosh extract (root) – Black cohosh is probably the most widely used nutraceutical for menopause, with research demonstrating significant relief of menopausal symptoms. These include relief from hot flashes and night sweats, as well as menopause-related nervousness and moodiness.⁶¹ ⁶² ⁶³ ⁶⁴ ⁶⁵
HMR lignan (7-Hydroxymaitainesinol) – In one study, women received a low dose (36 mg) or high dose (72 mg) of HMR lignan. The low-dose group experienced a 44% decrease in the average number of hot flashes per week, and the high-dose group experienced a 55% decrease. Severity data revealed that the low-dose group had 88% fewer severe hot flashes at week 4 compared to baseline, and the high-dose group noted 79% fewer severe hot flashes compared to baseline at week 4.⁶⁶

Fertility

Many women are concerned with maintaining a healthy state of fertility, as reflected in the fact that the global fertility supplements market for women is substantial and growing. In 2023, it was valued at $2.05 billion and is projected to reach $3.52 billion by 2030.⁶⁷ There are a broad number of nutraceutical options for such supplements, but here are three good ones:

Chaste berry (Vitex agnus castus) – A clinical study on chaste berry extract was conducted with women who had fertility concerns. The results were that pregnancy, healthy menstruation, or improved concentrations of luteal hormones were achieved in 31 out of 66 women who were suitable for evaluation. 15 women conceived during the observation period.⁶⁸
Maca – This herb has a history of use for women’s sexual function. Maca’s fertility-enhancing properties were first described in 1653.⁶⁹ Some research⁷⁰ suggests Maca supports healthy levels of fertility hormones. In one study, it raised levels of estrogen and lowered levels of follicle-stimulating hormone (FSH).⁷¹ Lower levels of FSH are linked to a greater chance of pregnancy.
Vitamin D – Lower vitamin D levels were associated with more women not conceiving easily on their own, according to a 2017 study.⁷²  If you’re already pregnant, you can develop complications if your vitamin D levels aren’t within normal parameters. Another study reported that women with low levels of vitamin D had higher blood pressure in pregnancy, pre-eclampsia, and gestational diabetes than women with normal vitamin D levels.⁷³

Sleep Support

The size of the global sleep support supplement market was valued at $7.6 billion in 2024 and is projected to grow at a CAGR of 5.2% to $12.9 by 2030.⁷⁴ Examples of three evidence-based nutraceuticals that support healthy sleep and can be used in supplements include:

Phytomelatonin – Plant-derived melatonin (or phytomelatonin from St. John’s wort or tomatoes) offers a natural alternative to synthetic melatonin, while still providing the sleep-supportive properties. In fact, 1 mg and 3 mg of phytomelatonin were shown to be as effective as or more effective than 10 mg of synthetic melatonin in specific cohorts of participants in a large randomized, double-blind, placebo-controlled clinical trial.⁷⁵ In another study, participants fell asleep 33% faster when using phytomelatonin derived from tomato fruit extract.⁷⁶
Glycine – Supplementation with glycine has been shown to help lower body core temperature, which makes it easier to fall asleep.⁷⁷
GABA – This nutraceutical helps create a sense of relaxation⁷⁸ ⁷⁹, making it easier to calm the mind before bedtime.

Beauty-From-Within

The beauty-from-within supplements category consists of supplements for skin, hair, and nails, or a combination of all of these. The estimated value of the global beauty supplement market size was $3.56 billion in 2022 and is projected to reach $9.22 billion in 2031 with a CAGR of 11.4% during the forecast period of 2023 to 2031.⁸⁰

Skin Health

Skin health supplements address various aspects of skin appearance. Most frequently, this tends to include fine lines and wrinkles, dryness/moisturization, and skin elasticity. There are nutraceuticals with human clinical research to promote these aspects of healthy skin appearance. Examples include:

Collagen peptides – Promote collagen production in skin, help reduce fine lines/wrinkles, promote skin moisturization and elasticity.
Ceramides – Substantially promotes skin moisturization, reduces transepidermal water loss, improves dryness and elasticity.
Astaxanthin – Antioxidant protection, suppresses damage to skin barrier function, helps reduce fine lines/wrinkles, promotes skin moisturization and elasticity.
Hyaluronic acid – Binds to water to help maintain hydration.

Hair Health

Hair health supplements address two aspects of hair appearance: hair growth/shedding and hair thickness. Select nutraceuticals with human clinical research to promote these aspects of healthy hair appearance, including:

Spermidine – Supports the anagen phase of hair growth, reduces hair shedding, and promotes hair thickness.
Pomegranate extract – Helps promote hair growth and hair thickness.
Solubilized keratin – Helps reduce hair shedding, supports the hair cycle, and supports stronger, shinier hair.

Nail Health

Nail health supplements address splitting, thickness, hardness, and the tendency to break. The three nutraceuticals with human clinical research to promote these aspects of healthy nail appearance include:

Spermidine (from rice germ extract) – Demonstrated to increase both nail growth and nail thickness.
Biotin – May help decrease fingernail splitting and improve nail thickness.
Solubilized keratin – Helps improve nail hardness and reduces the tendency to break.

Gut Health Supplements

Gut health has become an increasingly central focus in both preventive healthcare and daily wellness routines, as more consumers recognize its profound influence on overall health. A well-balanced gut microbiome supports not only digestion but also immune function, mood regulation, metabolic efficiency, and nutrient absorption. As a result, gut health supplements are now considered a foundational element of modern nutrition strategies.

These products work by maintaining healthy levels of beneficial gut flora, which is essential for digestive balance and effective nutrient uptake. Given its systemic influence, gut health is now widely regarded as a core indicator of long-term wellness.⁸¹ Two of the most important categories within this space are microbiome-supporting supplements and fiber-based supplements.

Microbiome-Supporting Supplements

Probiotics remain the cornerstone of gut health supplementation. These live microorganisms form the core of the gut’s microbiome, the ecosystem of beneficial bacteria and other microbes that play a critical role in maintaining digestive and immune health.

The global probiotics market is projected to grow from $86.81 billion in 2025 to $132.78 billion by 2029, reflecting a CAGR of 11.2%.⁸² This growth is driven by strong consumer demand and compelling scientific support. Probiotic supplements assist with digestive function by breaking down food molecules in the small intestine and interacting with bile acids to enhance fat digestion.⁸³ Additionally, they help form a microbial defense barrier in the gut, producing antimicrobial substances that inhibit the growth of harmful microbes.⁸⁴ ⁸⁵

Additionally, probiotics such as Lactobacillus acidophilus and Bifidobacterium bifidum have been shown to influence specific aspects of immune function, including the promotion of antibody and immunoglobulin (IgA) function.⁸⁶

It should be noted that, in addition to the gut, probiotics also offer benefits for supporting oral cavity (mouth) health. Specifically, when dissolved in the mouth rather than swallowed, the Streptococcus salivarius K12 strain helps maintain a healthy balance of bacteria in the mouth, as well as in the nasopharynx (the top part of the throat connecting the nose and respiratory system), and even extends benefits to the ears.⁸⁷ In addition, the Streptococcus salivarius K12 strain also helped maintain fresh breath.⁸⁸ ⁸⁹ ⁹⁰

Fiber-Based Supplements

Dietary fiber is another critical component of gut health, supporting regular bowel function and acting as a key nutrient for probiotic bacteria. The Recommended Daily Value for dietary fiber is 28 g for adults and children 4 or more years of age⁹¹, yet most individuals fall short of this target.

Fiber helps maintain digestive regularity, reduces constipation risk, and promotes satiety, which helps individuals better manage their appetite and weight. Specific prebiotic fibers serve as fuel for probiotics, enabling their survival and growth within the gut.

Psyllium husk, a well-known soluble fiber, has been shown to be an effective treatment for simple constipation, and its use has been associated with better stool consistency and a low incidence of adverse events.⁹² Other prebiotics, such as Oligofructose and oligofructose-enriched inulin (OEI) derived from Chicory root, have been shown to help users reduce their caloric intake.⁹³ ⁹⁴

Prebiotic fibers, such as fructooligosaccharides (FOS), xylooligosaccharides (XOS), and acacia gum, have been shown to increase Bifidobacterium probiotic counts.⁹⁵ ⁹⁶ ⁹⁷ Furthermore, galactooligosaccharides (GOS) have shown potential in supporting a healthy mood by modulating the gut microbiota.⁹⁸ In addition, FOS, inulin, and polyphenols all have prebiotic properties that have been shown to enhance Akkermansium mucinipahila.⁹⁹

Performance & Recovery Supplements

Performance and recovery supplements represent a major segment of the broader sports nutrition supplement category, which was valued at $48.58 billion in 2024 and is projected to reach $75 billion by 2030, growing at a CAGR of 7.5%.¹⁰⁰

This growth is fueled by increasing public awareness of the health risks associated with sedentary lifestyles, alongside a growing cultural emphasis on physical fitness, strength, and recovery. As more consumers adopt structured exercise routines and athletic training regimens, the demand for targeted supplementation to enhance performance and accelerate recovery has surged.

Two popular subcategories of performance and recovery supplements include creatine and nitric oxide products.

Creatine Powders

The global creatine supplements market size was valued at $1 billion in 2024 and is projected to reach 2.8 billion by 2030, growing at a CAGR of 17.9%.¹⁰¹ This explosive growth is supported by a substantial body of clinical research confirming creatine’s efficacy in energy production, lean muscle development, and enhancement of athletic performance.¹⁰²

Several forms of creatine are available on the market, including creatine monohydrate, creatine ethyl ester, creatine hydrochloride, creatine magnesium chelate, and creatine nitrate. However, creatine monohydrate remains the most widely used and clinically validated form.¹⁰³ It is the form most frequently utilized in human studies and has been consistently shown to increase intramuscular creatine concentrations, which directly supports strength, power output, and exercise endurance.

Beyond its role in performance enhancement, creatine has been studied for its benefits in post-exercise recovery, injury prevention, thermoregulation, rehabilitation, and even neuroprotection, making it one of the most versatile and well-researched ergogenic aids available.¹⁰⁴

A standard daily dose of creatine monohydrate is 5 grams, which is why it is typically delivered in powder form, either packaged in bottles/canisters or single-serve stick packs for on-the-go convenience.

Nitric Oxide Supplements

Nitric oxide (NO) is a naturally occurring compound in the body that promotes vasodilation, or the widening of blood vessels, which leads to increased blood flow. For physically active individuals, enhanced circulation can result in a range of exercise-related benefits, including improved oxygen and nutrient delivery, reduced fatigue, and greater endurance.

Nutraceuticals that boost nitric oxide production have gained popularity for their ability to support work capacity, recovery, and exercise tolerance. Among the most effective NO-boosting supplements are beetroot extract and the amino acid L-citrulline.

For example, beetroot supplements help boost NO production because they contain nitrates¹⁰⁵, which the body can convert into NO. In one study, beetroot increased total work performed and cardiac output during exercise¹⁰⁶, and significantly improved muscle energy use and oxygen delivery during low-oxygen exercise and subsequent recovery, as well as enhanced tolerance for high-intensity exercise.

The amino acid L-citrulline has also been shown to significantly increase NO levels and physical performance markers while improving subjective feelings of muscle fatigue and concentration immediately after exercise. It’s also been shown to support healthy circulation.¹⁰⁷ ¹⁰⁸ ¹⁰⁹

Shilajit

Shilajit is a pale-brown to blackish-brown exudate secreted from sedimentary rocks, primarily in the Himalayan region. It is composed of rock humus, mineral-rich organic matter, and microbial metabolites compressed over centuries within layers of rock and marine organisms.¹¹⁰

Long revered in Ayurvedic medicine, Shilajit has been used for over 3,000 years as a rejuvenating tonic and adaptogen to support vitality, endurance, and systemic resilience.¹¹¹ It remains one of the most important substances in the Ayurvedic materia medica. Modern clinical research¹¹² has begun to validate many of these traditional uses. Studies have shown that Shilajit can increase nitric oxide (NO) levels by approximately 30%, supporting enhanced circulation and vascular function. Other clinical research¹¹³ ¹¹⁴ has demonstrated its ability to improve exercise endurance and elevate ATP production—a key energy molecule critical to cellular metabolism and performance. Studies¹¹⁵ ¹¹⁶ have also shown that shilajit was able to increase levels of serum testosterone in men.

Gaming Supplements

With an estimated 3 billion people worldwide engaged in video gaming and approximately 74% of U.S. households reporting at least one gamer, the eSports and gaming industry represents a rapidly expanding market segment. In the U.S. alone, 76% of individuals under 18, 67% of adults, and even 7% of seniors over 65 actively participate in gaming.¹¹⁷

The International Olympic Committee acknowledged the legitimacy of competitive video gaming in October 2017, recognizing eSports as a potential sporting activity.¹¹⁸ This acknowledgment has helped elevate gaming into mainstream cultural and economic relevance, creating significant opportunities for targeted dietary supplements formulated specifically for gamers.

Formulas in this space are designed to support cognitive function, visual performance, reaction time, and mental endurance, key areas of concern for competitive and recreational gamers alike. Several ingredients have demonstrated promise in clinical or preliminary research:

Inositol-enhanced arginine silicate has been shown to improve accuracy, decision-making, and reaction time during gaming sessions.¹¹⁹
Aronia melanocarpa extract (black chokeberry) has been associated with short-term improvements in eye-hand coordination, along with enhanced focus, energy, and overall mood.¹²⁰
Lutein and zeaxanthin, two carotenoids known for their eye health benefits, help protect against blue light damage from digital screens. Supplementation with these compounds has been shown to reduce eye strain, headaches, and visual fatigue, while also supporting visual performance in digital environments.¹²¹ ¹²² ¹²³ ¹²⁴ ¹²⁵

As gaming continues to gain ground as both a recreational and professional activity, demand for specialized nutrition solutions tailored to this audience is expected to grow in parallel.

Herbal Supplements

The global herbal supplements market was valued at $52.43 billion in 2024 and is projected to reach $87.98 billion by 2032 at a CAGR of 9%.¹²⁶

This sustained growth is largely driven by rising consumer interest in natural health solutions and the increasing body of clinical research supporting the efficacy of herbal ingredients. As awareness expands around the preventive and therapeutic benefits of herbal supplementation, demand continues to rise across global markets.

Among the most widely studied and recognized botanicals are ginger, saffron, and turmeric—each offering unique and well-documented benefits related to inflammation, cognitive function, mood, and digestive health. These ingredients serve as cornerstone components in both traditional systems of medicine and modern integrative health protocols.

Ginger Supplements

Ginger is a traditional carminative (gas-relieving) herb.¹²⁷ Animal research has shown that ginger is capable of enhancing the activity of fat and carbohydrate digestive enzymes.¹²⁸

It is often added to combination formulas as a means of enhancing the absorption and utilization of the other herbs in the product. Its predominant uses are associated with its ability to help reduce common, occasional nausea¹²⁹, including nausea associated with morning sickness.¹³⁰ ¹³¹ Additionally, ginger has shown potential to reduce exercise-related discomfort and inflammation in otherwise healthy individuals who engage in strenuous physical activity.¹³²

Saffron Supplements

Crocus sativus L, commonly known as saffron, is a medicinal flowering plant cultivated in many countries, including Iran, Afghanistan, Turkey, and Spain, where it has been widely used to promote human health, particularly mood modulation.

Modern studies suggest that saffron’s mood-enhancing effects may stem from its influence on neurotransmitter levels, particularly by increasing serotonin¹³³, dopamine, and glutamine concentrations in the brain.¹³⁴ Multiple human clinical trials have demonstrated saffron’s ability to support a positive mood and reduce symptoms associated with emotional stress, making it a compelling natural option in the mood-support category.¹³⁵ ¹³⁶ ¹³⁷ ¹³⁸

Turmeric Supplements

According to American Botanical Council¹³⁹, the top-selling herbal supplement in the U.S. Natural Channel in 2022 was turmeric. Turmeric is a bright yellow, ancient spice and a traditional remedy that has been used as a traditional medicine, condiment, and flavoring based on records dating back to 600 BCE.

Its medicinal value is essentially due to its curcuminoid content. The curcuminoids inhibit 5-lipo-oxygenase (LOX) and cyclo-oxygenase (COX), resulting in a well-established anti-inflammatory action.¹⁴⁰ Turmeric and its curcuminoids also exhibit strong antioxidant activity¹⁴¹, enhance cellular resistance to oxidative damage¹⁴², and enhance the body’s natural antioxidant glutathione levels, which in turn aids the liver in detoxification.¹⁴³

Hydration Supplements

The hydration and electrolyte supplement category continues to show impressive growth. In 2024, the global market reached an estimated $36 billion, and is projected to expand to $82.7 billion by 2034, with a CAGR of 7.9%.¹⁴⁴ In the U.S. market alone, SPINS data from September 2024 reported a remarkable 49.3% year-over-year increase in category growth.¹⁴⁵

This surge in demand is fueled by dual consumer motivations: maintaining hydration for active lifestyles and supporting skin moisture and appearance, a growing interest among beauty-conscious consumers.

Astaxanthin – Shown to improve skin dryness, provide antioxidant protection, and support some measure of younger-looking skin.¹⁴⁶ ¹⁴⁷ ¹⁴⁸
Ceramides – Demonstrated to promote skin moisturization, reduce trans epidermal water loss, and improve dryness and elasticity.¹⁴⁹
Collagen peptides – Found to promote skin moisturization and elasticity, promote collagen production in skin, and help reduce fine lines/wrinkles.¹⁵⁰ ¹⁵¹

For those with physically active lifestyles, the foundation of any effective hydration formula remains electrolytes—including sodium, potassium, magnesium, and calcium—which are essential for fluid balance, muscle function, and recovery during and after exercise.

As consumers increasingly seek comprehensive hydration solutions that address both performance and aesthetic wellness, this category is well-positioned for continued innovation and expansion.

2026 Supplement Manufacturing Trends

In addition to trends within specific supplement categories, there are also supplement manufacturing trends to consider as a brand owner. Some of these trends include personalization in supplement manufacturing, advanced delivery forms, and third-party certifications.

Personalization in Supplement Manufacturing

Personalized supplements that cater to an individual’s unique health needs are the wave of the future and are not yet commonplace in the dietary supplement industry. Certainly, there are some limited services offering DNA, lifestyle, and microbiome analyses, and the results of those analyses may, in part, be used to personalize supplements for consumers. Likewise, wearable devices such as the Oura ring and Apple Watch may also play a role in tailoring supplement solutions to meet specific consumer goals. AI-directed recommendations for personalized supplements have not yet achieved scientific veracity.

Meanwhile, supplement personalization is currently geared toward a focus on demographic (e.g., gender, age-group) and condition-specific/lifestyle-specific considerations. For example, as a brand owner, you may choose to develop active lifestyle products for women in a specific age group. To those women, such products will be personalized for their needs. Similarly, giving careful consideration to the white space in the industry and developing products to meet currently unmet needs for specific populations is a viable approach to personalized supplementation.

Advanced Delivery Forms

Before exploring emerging delivery systems, it’s important to understand how current formats are performing in the market. According to SPINS data for the 52 weeks ending June 16, 2024¹⁵², the leading delivery forms for dietary supplements by dollar share are:

Gummies: 18.9%
Capsules (gelatin and vegan): 14.7%
Tablets: 13%
Softgels: 11.5%
Powders: 7.2%

However, the year-over-year percentage change in dollar sales tells a more nuanced story:

Powders: +8%
Capsules: +5.3%
Tablets: -0.9%
Gummies: -8%

This data suggests that powders and capsules are trending upward, while gummies are seeing a notable decline and tablets are experiencing a slight downward trend. For brands looking to optimize product format based on consumer preferences, powders and capsules are currently the most promising conventional options.

But what about other advanced delivery forms such as chewable, effervescent and fast-melt tablets? Many consumers have difficulty swallowing pills¹⁵³ and/or experience pill fatigue from having to swallow too many conventional tablets or capsules. This has caused many consumers to seek alternative delivery forms for dietary supplements¹⁵⁴—such as chewable, effervescent, and fast-melt tablets.

Chewable tablets – Chewable tablets that are specially formulated to deliver their nutraceuticals within a matrix of highly palatable flavor options, sweetening options, a desirable mouth feel, and good stability. One scientific journal described this delivery form in this way: “Chewable tablets are versatile dosage forms that combine the manufacturing and stability advantages of solid dosage products while offering beneficial organoleptic [flavor/taste] and administration benefits.”¹⁵⁵
Effervescent tablets – Effervescent tablets are typically round tablets that are larger than regular tablets and are designed to be placed in a glass of water, where they fizz and dissolve into the liquid. Microencapsulated and controlled-release effervescent tablets offer the potential for faster absorption of active ingredients. Research has demonstrated that effervescent tablets offer superior absorption in some cases. For example, one study¹⁵⁶ found that effervescent and fast-melting Q10 were more rapidly absorbed than softgel and powder-filled hard-shell capsules. Another study¹⁵⁷ reported that an effervescent form of calcium resulted in significant increases in serum calcium, a reflection of effective calcium absorption via effervescence.
Fast-melt tablets – Fast-melt tablets dissolve quickly in the mouth (within a minute or so) without the need for water. Research has also demonstrated enhanced bioavailability with fast-melt tablets. One study found that when used in fast-melt tablet form, vitamin B12 had good bioavailability, raising serum levels by as much as fourfold.¹⁵⁸ A similar human study¹⁵⁹ also found that fast-melt tablets increased serum concentrations by about threefold. Good results were also seen with fast-melt melatonin tablets.¹⁶⁰

Third-Party Certifications

Manufacturers often claim to follow FDA nutraceutical guidelines, operate out of quality contract manufacturing facilities, or perform cGMP contract manufacturing. However, these claims do not guarantee adherence to cGMPs. True assurance comes from GMP certification.

A GMP-certified facility has been audited for cGMPs by a credible third-party agency, ensuring compliance with industry standards. Among the best of the GMP certifications is the NSF GMP certification. GMP certification should be the minimum expected. Manufacturers can go beyond this by also being NSF Certified for Sport. This certification provides athletes, coaches, dieticians, and consumers with extra assurance about supplement safety. In addition, manufacturers can offer Kosher, Halal, and certified organic products, meeting various consumer preferences.

Another consideration is the rare but globally recognized standard in the food and supplement industry known as FSSC 22000 certification for food safety. All these certifications can potentially give your products a competitive edge.

Conclusion

As the nutraceutical landscape continues to evolve, staying ahead of 2026 supplement trends is essential for brand owners, manufacturers, and marketers alike.

With category growth in areas such as plant-based proteins, nootropics, gut health, and hydration, alongside rising demand for advanced delivery forms and third-party certifications, the market is becoming both more innovative and more competitive.

Consumers are increasingly informed and selective, favoring products that combine efficacy, transparency, and convenience. By aligning product development with emerging science, evolving consumer preferences, and validated quality standards, companies can position themselves for success in the next wave of supplement innovation.

Are you ready to capitalize on the 2026 supplement trends covered in this article? If so, call 800-526-9095 to speak with one of our knowledgeable sales executives or request a nutraceutical manufacturing price quote if you’ve already finalized your project requirements!

Request Pricing

Frequently Asked Questions About Supplement Trends for 2026

How are personalized supplements becoming more popular?

Personalized supplements are gaining in popularity with the idea that services offering DNA, lifestyle, and microbiome analyses, as well as wearable devices such as the Oura ring and Apple Watch, may help provide guidance on personalized supplements for consumers. However, this goal hasn’t been fully achieved. Meanwhile, consumers can look for supplements that are formulated with a focus on demographic (e.g., gender, age-group) and condition-specific/lifestyle-specific considerations that correlate with their personal needs.

What are the benefits of clean-label supplements?

There is no official definition of “clean label”. However, products with the absence of additives (or at least their minimal use) are generally considered to be clean label. An example would be the elimination of excipients such as magnesium stearate in favor of acceptable alternatives (e.g., rice-based materials). Also, the use of natural ingredients and sustainable, environmentally friendly positioning are considered clean-label friendly. In fact, products are increasingly deemed to be clean label if they carry environmental benefits.

Are there any dietary supplements that are particularly popular among athletes?

Two of the most popular, commonly used, and scientifically validated supplements are protein, such as whey or pea protein isolate, and creatine monohydrate. For example, pea protein has been shown to have strong anti-fatigue effects, decrease lactic acid, increase muscle and liver glycogen, improve insulin levels, and offer strong antioxidant and immune activity. Likewise, creatine monohydrate has been shown to promote energy production, build lean muscle, and support athletic performance, while enhancing post-exercise recovery, injury prevention, thermoregulation, rehabilitation, and neuroprotection.

References

1
Dietary Supplements Market Size, Share & Trends Analysis Report By Ingredient (Vitamins, Minerals, Probiotics), By Form (Capsules, Gummies, Liquids), By End User, By Application, By Type, By Distribution Channel, By Region, And Segment Forecasts, 2024 – 2030. Grand View Research. Retrieved June 3, 2025 from https://www.grandviewresearch.com/industry-analysis/dietary-supplements-market-report.
2
Moloughney S. The state of supplements: U.S. Market Approaches $70 Billion. Nutraceutical World. April 2, 2025. Retrieved June 3, 2025 from https://www.nutraceuticalsworld.com/exclusives/the-state-of-supplements-u-s-market-approaches-70-billion/#:~:text=Top%20Markets,has%20settled%20to%205.2%25%20growth.
3
Plant-based Protein Market. Markets And Markets. Retrieved January 24, 2025 from https://www.marketsandmarkets.com/Market-Reports/plant-based-protein-market-14715651.html.
4
Gausserès N, Mahè S, Benamouzig R, Luengo C, Drouet H, Rautureau J, Tomè D. The gastro-ileal digestion of 15N-labelled pea nitrogen in adult humans. Br J Nutr. 1996 Jul;76(1):75-85.
5
Smith CE, Mollard RC, Luhovyy BL, Anderson GH. The effect of yellow pea protein and fibre on short-term food intake, subjective appetite and glycaemic response in healthy young men. Br J Nutr. 2012 Aug;108 Suppl 1:S74-80.
6
Abou-Samra R, Keersmaekers L, Brienza D, Mukherjee R, Macé K. Effect of different protein sources on satiation and short-term satiety when consumed as a starter. Nutr J. 2011 Dec 23;10:139.
7
Diepvens K, Häberer D, Westerterp-Plantenga M. Different proteins and biopeptides differently affect satiety and anorexigenic/orexigenic hormones in healthy humans. Int J Obes (Lond). 2008 Mar;32(3):510-8.
8
Claessens M, Calame W, Siemensma AD, Saris WH, van Baak MA. The thermogenic and metabolic effects of protein hydrolysate with or without a carbohydrate load in healthy male subjects. Metabolism. 2007 Aug;56(8):1051-9.
9
Li H, Prairie N, Udenigwe CC, Adebiyi AP, Tappia PS, Aukema HM, Jones PJ, Aluko RE. Blood pressure lowering effect of a pea protein hydrolysate in hypertensive rats and humans. J Agric Food Chem. 2011 Sep 28;59(18):9854-60.
10
Feng T, Huang Y, Tang Z, Wei D, Mo J. Anti-fatigue effects of pea (Pisum sativum L.) peptides prepared by compound protease. J Food Sci Technol. 2021 Jun;58(6):2265-2272. doi: 10.1007/s13197-020-04737-3. Epub 2020 Aug 19. PMID: 33967323; PMCID: PMC8076353.
11
Michelet M, Schluckebier D, Petit LM, Caubet JC. Food protein-induced enterocolitis syndrome – a review of the literature with focus on clinical management. J Asthma Allergy. 2017 Jun 27;10:197-207.
12
Purpura M, Lowery RP, Joy JM, De Souza EO, Kalman DS, et al. (2014) A Comparison of Blood Amino Acid Concentrations Following Ingestion of Rice and Whey Protein Isolate: A Double-Blind Crossover Study. J Nutr Health Sci 1(3): 306. doi: 10.15744/2393-9060.1.306
13
Joy JM, Lowery RP, Wilson JM, et al. The effects of 8 weeks of whey or rice protein supplementation on body composition and exercise performance. Nutr J. 2013; 12: 86.
14
Kalman D, Escalante A. P34 The body composition effects of extra protein in elite mixed martial artists undergoing frequent training over a six-week period. JISSN. 2017;14(Suppl 2):31.
15
Nootropic Supplement Market Size – By Type, Ingredient Type, Function, Distribution Channel Analysis, Share, Growth Forecast, 2025 – 2034. Global Market Insights. Retrieved June 4, 2025 from https://www.gminsights.com/industry-analysis/nootropic-supplements-market.
16
Brown RP, Gerbarg PL, Ramazanov Z. Rhodiola rosea: A Phytomedicinal Overview. HerbalGram 2002; 56:40-52.
17
Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue–a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000 Oct;7(5):365-71.
18
Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-9.
19
Shevtsov VA, Zholus BI, Shervarly VI, Vol’skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003 Mar;10(2-3):95-105.
20
Engels G, Brinckmann J. Bacopa. HerbalGram. 2011;91:1-4.
21
Morgan A, Stevens J. Does Bacopa monnieri Improve Memory Performance in Older Persons? Results of a Randomized, Placebo-Controlled, Double-Blind Trial. J Altern Complem Med. 2010; 16(7): 753–759.
22
Calabrese C, Gregory WL, Leo M, Kraemer D, Bone K, Oken B. Effects of a Standardized Bacopa monnieri Extract on Cognitive Performance, Anxiety, and Depression in the Elderly: A Randomized, Double-Blind, Placebo-Controlled Trial. J Altern Complem Med. 2008;14(6):707–713.
23
Roodenrys S, Booth D, Bulzomi S, Phipps A, Micallef C, Smoker J. Chronic effects of Brahmi (Bacopa monnieri) on human memory. Neuropsychopharmacology. 2002 Aug;27(2):279-81.
24
Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl). 2001 Aug;156(4):481-4.
25
Stough C, Downey LA, Lloyd J, Silber B, Redman S, Hutchison C, Wesnes K, Nathan PJ. Examining the nootropic effects of a special extract of Bacopa monniera on human cognitive functioning: 90 day double-blind placebo-controlled randomized trial. Phytother Res. 2008 Dec;22(12):1629-34.
26
Raghav S, Singh H, Dalal PK, Srivastava JS, Asthana OP. Randomized controlled trial of standardized Bacopa monniera extract in age-associated memory impairment. Indian J Psychiatry. 2006 Oct-Dec; 48(4): 238–242.
27
Pase MP, Kean J, Sarris J, Neale C, Scholey AB, Stough C. The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. J Altern Complement Med. 2012 Jul;18(7):647-52.
28
Stough C, Lloyd J, Clarke J, Downey LA, Hutchison CW, Rodgers T, Nathan PJ. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl). 2001 Aug;156(4):481-4.
29
Natural Health Product. Mushrooms. Health Canada. March 25, 2019: 28 pp.
30
Saitsu Y, Nishide A, Kikushima K, Shimizu K, Ohnuki K. Improvement of cognitive functions by oral intake of Hericium erinaceus. Biomed Res. 2019;40(4):125-131.
31
Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009 Mar;23(3):367-72.
32
Nagano M, Shimizu K, Kondo R, Hayashi C, Sato D, Kitagawa K, Ohnuki K. Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomed Res. 2010 Aug;31(4):231-7.
33
Postbiotic Supplements Market. Future Market Insights, Inc. Retrieved June 21, 2024 from https://www.futuremarketinsights.com/reports/postbiotic-supplements-market.
34
Hirose Y, Murosaki S, Yamamoto Y, et al. Daily Intake of Heat-Killed Lactobacillus plantarum L-137 Augments Acquired Immunity in Healthy Adults. J Nutr. 2006; 136: 3069–3073.
35
Arimori Y, Nakamura R, Hirose Y, et al. Daily intake of heat-killed Lactobacillus plantarum L-137 enhances type I interferon production in healthy humans and pigs. Immunopharmacol Immunotoxicol. 2012 Dec;34(6):937-43.
36
Hirose Y, Yamamoto Y, Yoshikai Y, Murosaki S. Oral intake of heat-killed Lactobacillus plantarum L-137 decreases the incidence of upper respiratory tract infection in healthy subjects with high levels of psychological stress. J Nutr Sci. 2013; 2: e39.
37
Tanaka Y, Hirose Y, Yamamoto Y, et al. Daily intake of heat-killed Lactobacillus plantarum L-137 improves inflammation and lipid metabolism in overweight healthy adults: a randomized-controlled trial. Eur J Nutr. 2020 Sep;59(6):2641-2649.
38
Depommier C, Everard A, Druart C, Plovier H, Van Hul M, Vieira-Silva S et al (2019) Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nat Med 25(7):1096–1103.
39
Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27(3):113-9.
40
Fry D, Morales M. A reexamination of the effects of creatine on muscle protein synthesis in tissue culture. J Cell Biol. 1980; 84(2): 294-297.
41
Ingwall JS, Weiner CD, Morales ED, Stockdale FE. Specificity of creatine in the control of muscle protein synthesis. J Cell Biol. 1974;62(1): 145-151.
42
Global Women’s Health And Beauty Supplements Market Size & Outlook. Horizon Grand View Research. Retrieved June 26, 2025 from https://www.grandviewresearch.com/horizon/outlook/womens-health-and-beauty-supplements-market-size/global
43
Urology Supplements Market Size, Share & Trends Analysis Report By Type (Multi-ingredient, Single Ingredient), By Application (Urinary Tract Infections, Kidney Health, Prostate Health), By Formulation, By Distribution Channel, By Region, And Segment Forecasts, 2024 – 2030. Grand view Research. Retrieved June 26, 2025 from https://www.grandviewresearch.com/industry-analysis/urology-supplements-market-report.
44
Howell AB, Botto H, Combescure C, Blanc-Potard AB, Gausa L, Matsumoto T, Tenke P, Sotto A, Lavigne JP. Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infect Dis. 2010 Apr 14;10:94.
45
Howell AB, Botto H, Combescure C, Blanc-Potard AB, Gausa L, Matsumoto T, Tenke P, Sotto A, Lavigne JP. Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infect Dis. 2010 Apr 14;10:94.
46
Nicolosi D, Tempera G, Genovese C, Furneri PM. Anti-Adhesion Activity of A2-type Proanthocyanidins (a Cranberry Major Component) on Uropathogenic E. coli and P. mirabilis Strains. Antibiotics (Basel). 2014;3(2):143-154. Published 2014 Apr 3. doi:10.3390/antibiotics3020143
47
Wagenlehner FM, Abramov-Sommariva D, Höller M, Steindl H, Naber KG. Non-Antibiotic Herbal Therapy (BNO 1045) versus Antibiotic Therapy (Fosfomycin Trometamol) for the Treatment of Acute Lower Uncomplicated Urinary Tract Infections in Women: A Double-Blind, Parallel-Group, Randomized, Multicentre, Non-Inferiority Phase III Trial. Urol Int. 2018;101(3):327-336. doi:10.1159/000493368.
48
Höller M, Steindl H, Abramov-Sommariva D, Wagenlehner F, Naber KG, Kostev K. Treatment of Urinary Tract Infections with Canephron® in Germany: A Retrospective Database Analysis. Antibiotics (Basel). 2021;10(6):685. Published 2021 Jun 8. doi:10.3390/antibiotics10060685.
49
Butler DSC, Wagenlehner F, Höller M, Abramov-Sommariva D, Steindl H, Naber KG. Phytotherapy (BNO 1045) of Acute Lower Uncomplicated Urinary Tract Infection in Women Normalizes Local Host Responses. Urol Int. 2023;107(8):778-784. doi:10.1159/000531206.
50
Beerepoot MA, ter Riet G, Nys S, et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Arch Intern Med. 2012;172(9):704-712. doi:10.1001/archinternmed.2012.777
51
Beerepoot MA, ter Riet G, Nys S, et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Arch Intern Med. 2012;172(9):704-712. doi:10.1001/archinternmed.2012.777
52
Anukam K, Osazuwa E, Ahonkhai I, et al. Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial. Microbes Infect. 2006;8(6):1450-1454. doi:10.1016/j.micinf.2006.01.003
53
Anukam K, Osazuwa E, Ahonkhai I, et al. Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial. Microbes Infect. 2006;8(6):1450-1454. doi:10.1016/j.micinf.2006.01.003
54
The U.S. Joins Other Countries With Large Aging Populations. United States Census Bureau. March 13, 2018. Retrieved June 26, 2025 from https://www.census.gov/library/stories/2018/03/graying-america.html#:~:text=Although%20declining%20fertility%20plays%20a,as%20older%20adults%20outnumber%20kids.
55
Pausing to learn more about menopause. Mayo Clinic Health System. November 30, 2021. Retrieved June 26, 2025 from https://www.mayoclinichealthsystem.org/hometown-health/speaking-of-health/too-embarrassed-to-ask-part-3#:~:text=Menopause%20is%20defined%20as%20the,of%20their%20lives%20in%20menopause.
56
Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, Heger PW. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006 Sep-Oct;13(5):744-59.
57
Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, Heger PW. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006 Sep-Oct;13(5):744-59.
58
Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, Heger PW. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006 Sep-Oct;13(5):744-59.
59
Kaszkin-Bettag M, Beck S, Richardson A, Heger PW, Beer AM. Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. Altern Ther Health Med. 2008 Nov-Dec;14(6):32-8.
60
Kaszkin-Bettag M, Ventskovskiy BM, Kravchenko A, Rettenberger R, Richardson A, Heger PW, Heger M. The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women. Menopause. 2007 Mar-Apr;14(2):270-83.
61
Ross SM. Menopause: a standardized isopropanolic black cohosh extract (remifemin) is found to be safe and effective for menopausal symptoms. Holist Nurs Pract. 2012 Jan-Feb;26(1):58-61.
62
Osmers R, Friede M, Liske E, Schnitker J, Freudenstein J, Henneicke-von Zepelin HH. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol. 2005;105(5 Pt 1):1074-83.
63
Frei-Kleiner S, Schaffner W, Rahlfs VW, Bodmer Ch, Birkhäuser M. Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial. Maturitas. 2005;51(4):397-404.
64
Wuttke W, Seidlová-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas. 2003;44 Suppl 1:S67-77.
65
Stoll W. Phytopharmacon influences atrophic vaginal epithelium: double blind study – cimicifuga vs. estrogenic substances. Source: Therapeutikum. 1987;1:23-31.
66
Udani JK, Brown DJ, Tan MOC, Hardy M. Pharmacokinetics and Bioavailability of Plant Lignan 7-Hydroxymatairesinol and Effects on Serum Enterolactone and Clinical Symptoms in Postmenopausal Women: A Single-Blinded, Parallel, Dose-Comparison Study. J Am Coll Nutr. Dec 2013;32(6):428–435.
67
Fertility Supplements Market Size, Share & Trends Analysis Report By Ingredient Type, Product Type, By End-user, By Distribution Channel, By Region, And Segment Forecasts, 2024 – 2030. Grand View Research. Retrieved June 26, 2025 from https://www.grandviewresearch.com/industry-analysis/fertility-supplements-market.
68
Gerhard II, Patek A, Monga B, et al. Mastodynon for female infertility. (abstract) Forsch Komplementarmed 1998;5:272-8.
69
Gonzales GF. Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands. Evid Based Complement Alternat Med. 2012; 2012: 193496.
70
Stojanovska L, Law C, Lai B, et al. Maca reduces blood pressure and depression, in a pilot study in postmenopausal women. Climacteric. 2015;18(1):69-78.
71
Meissner HO, Mscisz A, Reich-Bilinska H, et al. Hormone-Balancing Effect of Pre-Gelatinized Organic Maca (Lepidium peruvianum Chacon): (II) Physiological and Symptomatic Responses of Early-Postmenopausal Women to Standardized doses of Maca in Double Blind, Randomized, Placebo-Controlled, Multi-Centre Clinical Study. Int J Biomed Sci. 2006;2(4):360-374.
72
Fung JL, et al. Association of vitamin D intake and serum levels with fertility: results from the Lifestyle and Fertility Study. Fertility and Sterility. 2017; 108(2): 302 – 311/
73
Purswani J, Gala P, Dwarkanath P, et al. The role of vitamin D in pre-eclampsia: a systematic review. BMC Pregnancy Childbirth. 2017; 17: 231. https://doi.org/10.1186/s12884-017-1408-3
74
Weight Loss Supplement Market Trends. Grand View Research. Retrieved May 23, 2024 from https://www.grandviewresearch.com/industry-analysis/weight-loss-supplements-market-report.
75
Pauli EK, et al. A Randomized, Blinded, Placebo-Controlled Direct to-Consumer Study of Health and Wellness Products on Sleep and Other Health Outcomes. Radicle Science. 2024; unpublished.
76
De Jesus M, Berquist K, Bruno G. Effects of Somato® tomato fruit extract on key physiological and psychological domains associated with sleep quality, autonomic function, and health-related quality of life (HRQoL) – A Pilot Study. 2025. Submitted for publication.
77
Bannai M, Kawai N. New therapeutic strategy for amino acid medicine: glycine improves the quality of sleep. J Pharmacol Sci. 2012;118(2):145-148. doi:10.1254/jphs.11r04fm
78
Abdou AM, Higashiguchi S, Horie K, Kim M, Hatta H, Yokogoshi H. Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. Biofactors. 2006;26(3):201-8.
79
Yamatsu A, Yamashita Y, Maru I, Yang J, Tatsuzaki J, Kim M. The Improvement of Sleep by Oral Intake of GABA and Apocynum venetum Leaf Extract. J Nutr Sci Vitaminol (Tokyo). 2015;61(2):182-7.
80
The estimated value of the global beauty supplement market size was $3.56 billion in 2022 and is projected to reach $9.22 billion in 2031 with a compounded annual growth rate (CAGR) of 11.4% during the forecast period of 2023 to 2031.
81
Digestive Health Products Market Size, Share, and Growth Analysis. Skyquest. Retrieved June 4, 2025 from https://www.skyquestt.com/report/digestive-health-products-market.
82
Probiotics Market Report 2025. Research and Markets. Retrieved June 4, 2025 from https://www.researchandmarkets.com/reports/5744225/probiotics-market-report#:~:text=The%20probiotics%20market%20size%20has,(CAGR)%20of%209.1%25.
83
Plaza-Diaz J, Ruiz-Ojeda FJ, Gil-Campos M, Gil A. Mechanisms of Action of Probiotics. Adv Nutr. 2019 Jan 1;10(suppl_1):S49-S66. doi: 10.1093/advances/nmy063. Erratum in: Adv Nutr. 2020 Jul 1;11(4):1054. doi: 10.1093/advances/nmaa042. PMID: 30721959; PMCID: PMC6363529.
84
Lievin V, Peiffer I, Hudault S, et al. Bifidobacterium strains from resident infant human gastrointestinal microflora exert antimicrobial activity. Gut 2000;47:646-52.
85
Rastall RA. Bacteria in the gut: friends and foes and how to alter the balance. J Nutr 2004;134:2022S-2026S.
86
Erickson KL, Hubbard NE. Probiotic Immunomodulation in Health and Disease. J Nutr. 2000;130:403S–409S.
87
Di Pierro F, Adami T, Rapacioli G, Giardini N, Streitberger C. Clinical evaluation of the oral probiotic Streptococcus salivarius K12 in the prevention of recurrent pharyngitis and/or tonsillitis caused by Streptococcus pyogenes in adults. Expert Opin Biol Ther. 2013 Mar;13(3):339-43.
88
Masdea L, Kulik EM, Hauser-Gerspach I, Ramseier AM, Filippi A, Waltimo T. Antimicrobial activity of Streptococcus salivarius K12 on bacteria involved in oral malodour. Arch Oral Biol. 2012 Aug;57(8):1041-7.
89
Masdea L, Kulik EM, Hauser-Gerspach I, Ramseier AM, Filippi A, Waltimo T. Antimicrobial activity of Streptococcus salivarius K12 on bacteria involved in oral malodour. Arch Oral Biol. 2012 Aug;57(8):1041-7.
90
Burton JP, Chilcott CN, Tagg JR. The rationale and potential for the reduction of oral malodour using Streptococcus salivarius probiotics. Oral Dis. 2005;11 Suppl 1:29-31.
91
Daily Values. National Institutes of Health, Office of Dietary Supplements. Retrieved June 4, 2025 from https://ods.od.nih.gov/HealthInformation/dailyvalues.aspx.
92
Dettmar PW, Sykes J, Curr Med Res Opin (1998) 14(4):227-33.
93
McCann MT, Livingstone MBE, Wallace JMW, Gallagher AM, Weich RW. T1:P.082 Oligofructose-enriched Inulin supplementation decreases energy intake in overweight and obese men and women. Obes Rev. 2011;12 (Suppl. 1): 86-87.
94
Verhoef SP, Meyer D, Westerterp KR. Effects of oligofructose on appetite profile, glucagon-like peptide 1 and peptide YY3-36 concentrations and energy intake. Br J Nutr. 2011 Dec;106(11):1757-62.
95
Bouhnik Y, Ouarne FF, Riottot M et al. Effects of prolonged ingestion of fructo-oligosaccharides (FOS) on colonic bifidobacteria, fecal enzymes and bile acids in humans. Gastroenterology 1994;106:A598.
96
Finegold SM, Li Z, Summanen PH, Downes J, Thames G, Corbett K, Dowd S, Krak M, Heber D. Xylooligosaccharide increases bifidobacteria but not lactobacilli in human gut microbiota. Food Funct. 2014 Mar;5(3):436-45.
97
Salyers AA, Palmer JK, Wilkins TD. Degradation of polysaccharides by intestinal bacterial enzymes. Am J Clin Nutr. 1978;31:S128-S130.
98
Johnstone N, Milesi C, Burn O, van den Bogert B, Nauta A, Hart K, Sowden P, Burnet PWJ, Cohen Kadosh K. Anxiolytic effects of a galacto-oligosaccharides prebiotic in healthy females (18-25 years) with corresponding changes in gut bacterial composition. Sci Rep. 2021 Apr 15;11(1):8302. doi: 10.1038/s41598-021-87865-w. PMID: 33859330; PMCID: PMC8050281.
99
Zhou K. Strategies to promote abundance of Akkermansia muciniphila, an emerging probiotics in the gut, evidence from dietary intervention studies. J Funct Foods. 2017 Jun;33:194-201. doi: 10.1016/j.jff.2017.03.045. Epub 2017 Mar 29. PMID: 30416539; PMCID: PMC6223323.
100
Sports Nutrition Market Size, Share & Trends Analysis Report By Product Type (Sports Supplements, Sports Drinks), By Formulation, By Consumer Group, By Sales Channel, By Region, And Segment Forecasts, 2024 – 2030. Grand View Research. Retrieved June 4, 2025 from https://www.grandviewresearch.com/industry-analysis/sports-nutrition-market#:~:text=The%20global%20sports%20nutrition%20market%20size%20was,(CAGR)%20of%207.5%%20from%202024%20to%202030.&text=The%20global%20sports%20nutrition%20market%20size%20was,to%20reach%20USD%2048.58%20billion%20in%202024.
101
Creatine Supplements Market Size & Trends. Grand View Research. Retrieved January 14, 2025 from https://www.grandviewresearch.com/industry-analysis/creatine-supplements-market-report.
102
Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. JISSN. 2017;14:18.
103
Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. JISSN. 2017;14:18.
104
Kreider RB, Kalman DS, Antonio J, et al. International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. JISSN. 2017;14:18.
105
Hord NG, Tang Y, Bryan NS. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009 Jul;90(1):1-10.
106
Zamani P, Rawat D, Shiva-Kumar P, et al. Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction. Circulation. 2015 Jan 27;131(4):371-80.
107
Suzuki T, Morita M, Kobayashi Y, Kamimura A. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study. J Int Soc Sports Nutr. 2016 Feb 19;13:6.
108
Cormio L, De Siati M, Lorusso F, Selvaggio O, Mirabella L, Sanguedolce F, Carrieri G. Oral L-citrulline supplementation improves erection hardness in men with mild erectile dysfunction. Urology 2011;77:119-22.
109
Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina A, Spickler W, Schulze F, and Böger RH. Pharmacokinetic and pharmacodynamic properties of oral L-citrulline and L-arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol 2008;65:51-9.
110
Ghosal, S. The aroma principles of Gomutra and Karpuragandha Shilajit. Indian J Indg Med 1994;11:11–14.
111
David, F. and Vasant, L. 2001. The Yoga of Herbs. Twin Lakes, WI: Lotus Press.
112
Rani PU, Sravanti IV, Fatima N, Muralidhar N. Salomi R. Study of Shilajit ( PrimaVie®) in modifying cardiovascular risk with special reference to Endothelial dysfunction in patients with Type2 Diabetes Mellitus. Department of Clinical Pharmacology and Therapeutics, Nizam’s Institute of Medical SciencesPunjagutta, Hyderabad, Andhra Pradesh, India. Submitted for publication. 2014.
113
Maharaj V, Tripathi PC, Tripathi S, Banerjee D, Islam A. Clinical Evaluation of Safety & Efficacy of Shilajit (PrimaVie-Shilajit for Improving Human Performance In Exercise Study of Healthy Volunteers – a Placebo controlled Study. Final Report Project No.: NAT/CR/20100901. Ramakrishna Mission Ashrama Hospital(Ayurvedic Unit), Narendrapur, Kolkata-700103. 2012.
114
Ghosal S, Pal D, Bhattacharyya S. Pilot Study on the Improvement of Human Performance with PrimaVie® as Energy Booster: Part-IV. Project No.: NAT/CHEM-7/09/06. Natreon Inc. (India), Kolkata CL-18A, Salt Lake City. Sector-II, Kolkata 700 091. 2006.
115
Biswas TK, Pandit S, Mondal S, Biswas SK, Jana U, Ghosh T, Tripathi PC, Debnath PK, Auddy RG, Auddy B. Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. Andrologia. 2010 Feb;42(1):48-56.
116
Pandit S, Biswas S, Jana U, De RK, Mukhopadhyay SC, Biswas TK. Clinical evaluation of purified shilajit on testosterone levels in healthy volunteers. Research Unit, J. B. Roy State Ayurvedic Medical College and Hospital, Department of Health and Family Welfare, Government of West Bengal, Kolkata, India. Submitted for publication. 2014.
117
Gaming Statistics. TrueList. 5/24/22. Retrieved June 22, 2022 from https://truelist.co/blog/gaming-statistics/#:~:text=Over%20227%20million%20people%20in,than%2065%20play%20video%20games.
118
Grohmann, Karolos (28 October 2017). ”E-sports just got closer to being part of the Olympics”. Reuters. Retrieved 5 November 2017.
119
Tartar JL, Kalman D, Hewlings S. A Prospective Study Evaluating the Effects of a Nutritional Supplement Intervention on Cognition, Mood States, and Mental Performance in Video Gamers. Nutrients. 2019 Oct; 11(10): 2326.
120
Proprietary Aronia berry extract improves acute and short-term gaming performance in a young, healthy gamer population: study report. BioActor B.V. Brightlands Health Campus Gaetano Martinolaan 85, 6229GS Maastricht, Netherlands. Unpublished. March 29, 2021: 19 pgs.
121
Stringham JM, O’Brien KJ, Stringham NT. Macular carotenoid supplementation improves disability glare performance and dynamics of photostress recovery. Eye Vis (Lond). 2016 Nov 11;3:30.
122
Stringham NT, Holmes PV, Stringham JM. Supplementation with macular carotenoids reduces psychological stress, serum cortisol, and sub-optimal symptoms of physical and emotional health in young adults. Nutr Neurosci. 2017 Feb 15:1-11.
123
Contrast sensitivity – Accepted (IOVS) in press
124
Stringham J. Effects of three levels of lutein supplementation on macular pigment optical density, psychological stress levels, and overall health. Nutritional Neuroscience Laboratory, University of Georgia. Unpublished. 2016:17 pgs.
125
Stringham JM et al. Short-term macular carotenois supplementation improves overall sleep quality. ARVO 2016 Annual Meeting Abstracts
126
Global Herbal Supplements Market Overview. Market Research Future. Retrieved July 30, 2024 from https://www.marketresearchfuture.com/reports/herbal-supplements-market-3231#:~:text=Herbal%20Supplements%20Market%20Size%20was,period%20(2024%20%2D%202032).
127
Blumenthal M, et al, (eds), The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. (1998) Austin: American Botanical Council and Boston: Integrative Medicine Communications, 425–26.
128
Platel K, Srinivasan K. Influence of dietary spices or their active principles on digestive enzymes of small intestinal mucosa in rats. Int J Food Sci Nutr 1996; 47(1):55-9.
129
Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. British journal of anesthesia 2000; 84(3):367-71.
130
Schouenborg LO, Honnens de Lichtenberg M, Djursing H, Sorensen J. Ugeskrift for laeger 1992; 154(15):1015-9.
131
Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1990;38:19–24.
132
Srivastava KC, Mustafa T, Med Hypotheses (1992) 39(4):342-8.
133
Hausenblas HA, Saha D, Dubyak PJ, Anton SD. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. J Integr Med. 2013 Nov;11(6):377-83.
134
Ettehadi Hosseinali, Seyedeh Nargesolsadat Mojabi, Mina Ranjbaran, Jamal Shams, Hedayat Sahraei, Mahdi Hedayati, Farzad A. Aqueous Extract of Saffron (Crocus sativus) Increases Brain Dopamine and Glutamate Concentrations in Rats. J Behav Brain Sci. 2013;3:315–319.
135
Is Safr’Inside™ efficient on mood in only 15 days? Proprietary consumer study. Customer Technical Support. CTS-0138. Active Inside. Update 01 from 03/05/2018. Elaboration date 18/10/2017: 2 pgs.
136
Akhondzadeh S Tahmacebi-Pour N, Noorbala AA, Amini H, Fallah-Pour H, Jamshidi AH, Khani M. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res. 2005 Feb;19(2):148-51.
137
Modabbernia A, Sohrabi H, Nasehi AA, Raisi F, Saroukhani S, Jamshidi A, Tabrizi M, Ashrafi M, Akhondzadeh S. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology (Berl). 2012 Oct;223(4):381-8.
138
Hausenblas HA, Saha D, Dubyak PJ, Anton SD. Saffron (Crocus sativus L.) and major depressive disorder: a meta-analysis of randomized clinical trials. J Integr Med. 2013 Nov;11(6):377-83.
139
Smith T, Bauman H, Resetar H. US Sales of Herbal Supplements Decline Slightly in 2022. HerbalGram. 2024; 139: 52-69.
140
Chandra D, Gupta S. Anti-inflammatory and anti-arthritic activity of volatile oil of Curcuma longa (Haldi). Ind J Med Res 1972; 60:138-142.
141
Toda S, Miyase T, Arich H, et al. Natural antioxidants. Antioxidative compounds isolated from rhizome of Curcuma longa L. Chem Pharmacol Bull 1985;33:1725-1728.
142
Mortellini R, Foresti R, Bassi R, Green CJ. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med 2000;28:1303-1312.
143
Pizorrno JE, Murray MT. Textbook of Natural Medicine, 2nd Ed. London: Churchill Livingstone; 1999;689-693.
144
Hydration Supplement Market Outlook from 2024 to 2034. Future Market Insights. Retrieved May 21, 2024 from https://www.futuremarketinsights.com/reports/hydration-supplement-market#:~:text=FMI%20estimates%20the%20global%20hydration,US%24%2082.7%20billion%20by%202034.
145
Casteel B. SPINS presentation. UNPA Member’s Retreat, Deer Valley, UT. September 2024.
146
Iwamoto T, Hosoda K, Hirano R, Kurata H, Matsumoto A, Miki W, Kamiyama M, Itakura H, Yamamoto S, Kondo K. Inhibition of low-density lipoprotein oxidation by astaxanthin. J Atheroscler Thromb. 2000;7(4):216-22.
147
Yamashita E. The Effects of a Dietary Supplement Containing Astaxanthin on Skin Condition. Carotenoid Science. 2006;10:91-95.
148
Chalyk NE, Klochkov VA, Bandaletova TY, Kyle NH, Petyaev IM. Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers. Nutr Res. 2017 Dec;48:40-48.
149
Bizot V, Cestone E, Michelotti A, Nobile V. Improving Skin Hydration and Age-related Symptoms by Oral Administration of Wheat Glucosylceramides and Digalactosyl Diglycerides: A Human Clinical Study. Cosmetics. 2017; 4:37.
150
Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27(3):113-9.
151
Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55.
152
Casteel B. SPINS presentation. UNPA Member’s Retreat, Deer Valley, UT. September 2024.
153
Hinote T. Trouble swallowing pills? Here’s what you can do about it. Orlando Health. Retrieved July 30, 2024 from https://www.orlandohealth.com/content-hub/trouble-swallowing-pills-heres-what-you-can-do-about-it#:~:text=Whether%20the%20cause%20is%20emotional,hint%20at%20something%20more%20serious.
154
Schultz H. Pill fatigue is driving innovation in space between function foods and supplements, experts say. November 20, 2014. Retrieved October 13, 2019 from https://www.nutraingredients-usa.com/Article/2014/11/20/Pill-fatigue-is-driving-innovation-in-space-between-functional-foods-and-supplements-experts-say.
155
Antil A, Kahiy M, Tomar D. An Overview on Efficacy of Chewable Tablets in Improving Oral Drug Delivery. Systemic Reviews in Pharmacy. 2023; 14(9): 571-7.
156
Joshi SS, Sawant SV, Shedge A, Halpner AD. Comparative bioavailability of two novel coenzyme Q10 preparations in humans. Int J Clin Pharmacol Ther 2003;41(1):42-8.
157
Sadideen H, Swaminathan R. Effect of acute oral calcium load on serum PTH and bone resorption in young healthy subjects: an overnight study. Eur J Clin Nutr 2004;58(12):1661-5.
158
Delpre G. Sublingual therapy for cobalamin deficiency as an alternative to oral and parenteral cobalamin Supplementation. Lancet. 1999;354:740-750.
159
Sharabi A, Cohen E, Sulkes J, Garty M. Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route. Br J Clin Pharmacol. 2003 Dec;56(6):635-8.
160
SaberMoghaddam M, Sheybani S, Bakhtiari E, Shakiba M. The Effect of Preoperative Sublingual Melatonin on Postoperative Pain Severity in Patients Undergoing Colorectal Surgery: A Triple-Blinded Randomized Trial. Med J Islam Repub Iran. 2022 Aug 10;36:90.

Lauren

Samot, RD

Commercial Innovation Leader

With almost a decade at Vitaquest, Lauren Samot’s journey from Technical Services Associate to her current role as Commercial Innovation Leader exemplifies her dedication and growth. Leading the innovation team, she fuels business expansion through collaborative efforts across sales, product development, and operations. With a 15-year long career in nutraceuticals, Lauren excels in manufacturing, raw materials, and formulation. A Vitaquest Proud Champion Award recipient twice, she holds a B.S. in Nutritional Science with a minor in Public Health from Boston University and is an accomplished Registered Dietitian and member of the Academy of Nutrition and Dietetics.