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The fall season creates unique opportunities in the supplement market. Find out which trends will boost your product lineup in this article!
An image featuring ginger root, lemon slices, and leaves, representing fall 2025 supplement trends.

Exploring the Fall 2025 Supplement Trends for Brand Owners

In 2023, the size of the global supplements market was $378.84 billion. It is projected to reach $745.94 billion by 2033, with a compounded annual growth rate (CAGR) of 7.01%.1Nutritional Supplements Market. The Brainy Insights. Accessed January 28, 2025 from https://www.thebrainyinsights.com/report/nutritional-supplements-market-13585.

While the supplement industry continues to enjoy healthy market growth, that growth can change seasonally. Naturally, there are various reasons for this.

Consider that our bodies not only follow the circadian rhythms of day and night but also adapt to the changing seasons. Research suggests that during the fall, people may experience a decline in physical health due to several factors, including reduced sunlight exposure, increased susceptibility to illness, and shifts in dietary habits, such as consuming heavier foods. Additionally, shorter daylight hours can impact mood, leading some individuals to feel more sluggish or down. As a result, fall often brings a heightened focus on health and immunity.2Seize the Season: Embracing Seasonality in Marketing Supplements for Fitness Coaches. DirectPayNet. May 26, 2023. Retrieved January 28, 2025 from https://directpaynet.com/marketing-supplements-seasonally-online-coaches/#:~:text=Consider%20the%20energy%20and%20optimism,optimize%20muscle%20growth%20and%20recovery.

In this article, we’ll explore the supplement trends expected to shape the Fall of 2025. We’ll highlight key categories poised for growth and discuss research-backed nutraceutical ingredients that can add value to your formulations.

 

Supplement Types Trending in Fall 2025

Several supplement categories are expected to gain traction in the Fall of 2025, including:

  • Immune-Boosting Supplements
  • Stress and Mood Support
  • Gut Health Solutions
  • Nutricosmetics
  • Women’s Health Supplements
  • Joint and Inflammation Support

Additionally, emerging trends focus on evidence-based ingredients, bioavailable and enhanced absorption formulations, multi-functional supplements, proactive health and preventive solutions, and personalized supplements tailored for precision wellness. This article will explore each of these trends in detail.

 

Immune-Boosting Supplements

Changes in immune health occur during the transition from summer to fall, with decreasing temperatures and changing daylight hours impacting the body’s immune system. This often results in a decline in immune function due to factors like reduced Vitamin D production from lower sunlight exposure, increased susceptibility to respiratory infections, and potential stress from environmental changes, making individuals more prone to illnesses.3Fares A. Factors influencing the seasonal patterns of infectious diseases. Int J Prev Med. 2013 Feb;4(2):128-32. PMID: 23543865; PMCID: PMC3604842.

Consequently, interest in immune support supplements rises during the fall months. This trend aligns with the global immune health supplement market, which was valued at $24.38 billion in 2023 and is projected to reach $44.04 billion by 2032, driven in part by seasonal health concerns.4Immune Health Supplements Market. Fortune Business Insights. Retrieved January 28, 2025 from https://www.fortunebusinessinsights.com/immune-health-supplements-market-103319. Some of the trends in immune health supplements include the following:

  • Vitamin D – This vitamin is a potent immune system modulator5Lin R, White JH. The pleiotropic actions of vitamin D. Bioessays. 2004;26(1):21-28. with a variety of effects on immune system function which may enhance innate immunity and promote normal immune function.6Griffin MD, Xing N, Kumar R. Vitamin D and its analogs as regulators of immune activation and antigen presentation. Annu Rev Nutr. 2003;23:117-145.
  • Vitamin C – This vitamin affects various components of the human immune response, including antimicrobial and natural killer cell activities, and lymphocyte (white blood cell) proliferation.7Khassaf M, McArdle A, Esanu C, Vasilaki A, McArdle F, Griffiths RD, Brodie DA, Jackson MJ. Effect of vitamin C supplements on antioxidant defence and stress proteins in human lymphocytes and skeletal muscle. J Physiol. 2003 Jun 1;549(Pt 2):645-52.
  • Vitamin K – Vitamin K-dependent proteins play important roles in various immunomodulatory and antioxidant functions. This includes inflammation, which is part of the immune process.8Xie Y, Li S, Wu D, et al. Vitamin K: Infection, Inflammation, and Auto-Immunity. J Inflamm Res. 2024;17:1147-1160. Published 2024 Feb 20. doi:10.2147/JIR.S445806
  • Vitamin A – This vitamin helps regulate the immune system by playing a role in the production of white blood cells that engulf bacteria and viruses.9Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. National Academy Press, Washington, DC, 2001.
  • Zinc – This mineral is integral to the immune system10Food and Nutrition Board, Institute of Medicine. Zinc. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, D.C.: National Academy Press; 2001:442-501., affecting multiple immune activities from lymphocyte gene regulation to the skin barrier,11Food and Nutrition Board, Institute of Medicine. Zinc. Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, D.C.: National Academy Press; 2001:442-501. and decreasing oxidative stress markers.12Prasad AS. Zinc in human health: effect of zinc on immune cells. Mol Med 2008; 14(5-6): 353-7.
  • Elderberry – This herb supports antibody production, is a clinically tested immune booster, and significantly improved immune measures in 48 hours according to a published study.13Zakay-Rones Z1, Varsano N, Zlotnik M, Manor O, Regev L, Schlesinger M, Mumcuoglu M. Inhibition of several strains of influenza virus in vitro and reduction of symptoms by an elderberry extract (Sambucus nigra L.) during an outbreak of influenza B Panama. J Altern Complement Med. 1995 Winter;1(4):361-9. 14Kong F. Pilot Clinical Study on a Proprietary Elderberry Extract: Efficacy in Addressing Influenza Symptoms, Online J Pharmacol Pharmacokin 5:32‐43, 2009. 15Kong F-K. Pilot Clinical Study on a Proprietary Elderberry Extract: Efficacy in Addressing Influenza Symptoms, Online J Pharmacol Pharmacokin. 2009; 5:32‐43.
  • AshwagandhaAshwagandha has been shown to support immune health, significantly promoting healthy levels of immunoglobulin antibodies, as well as immunomodulating cytokines and lymphocytes.16Tharakan a, Shukla H, Benny IR, et al. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract—A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med. 2021; 10(16): 3644.

 

Stress and Mood Support

Increased stress in the fall, often referred to as “autumn anxiety,” can be caused by a combination of factors.17Why Do Some People Feel More Anxious in the Fall? Mercy. October 9, 2023. Retrieved https://www.mercy.net/newsroom/2023-10-09/why-do-some-people-get-more-anxious-in-the-fall-/#:~:text=If%20you’re%20more%20stressed,the%20rest%20of%20the%20year.%E2%80%9D. Likewise, many people feel “down” or have the “winter blues” when the days get shorter in the fall and winter and feel better in the spring when longer daylight hours return.18Seasonal Affective Disorder. U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES, National Institutes of Health, NIH Publication No. 23-MH-8138. Revised 2023. Retrieved January 28, 2025 from https://www.nimh.nih.gov/health/publications/seasonal-affective-disorder#:~:text=Many%20people%20feel%20%22down%22%20or,feels%2C%20thinks%2C%20and%20behaves. These changes in stress and mood may lead to an increase in the use of supplements to help address these issues.

The global supplement market mirrors this trend, with the stress relief supplement market projected to grow from $605 million in 2024 to $1.03 billion by 2034, at a CAGR of 5.5%.19https://finance.yahoo.com/news/increasing-prevalence-cognitive-disorders-amid-123000914.html#:~:text=The%20stress%20relief%20supplement%20market%20is%20expected%20to%20reach%20a,US%24%20108%20million%20in%202034. Likewise, the value of the mood support market was estimated at $656 million in 2022 and is expected to reach $1.3 billion by the end of 2033, with a CAGR of 6.4%.20https://finance.yahoo.com/news/mood-support-supplements-market-hit-170000831.html

There is some overlap in these numbers since mood support supplements are considered by some to help reduce feelings of occasional stress and anxiety.

Some of the trends in dietary supplements for stress and mood include the following:

  • Ashwagandha – This adaptogenic herb is used for mental and emotional well-being and supports immune function and sexual health.21Lopresti AL, Smith SJ, Malvi H, Kodgule R. An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study. Medicine (Baltimore). 2019 Sep;98(37):e17186. 22Provino R. The role of adaptogens in stress management. Aust J Med Herbal. 2010;22:41-9 23Tharakan a, Shukla H, Benny IR, et al. Immunomodulatory Effect of Withania somnifera (Ashwagandha) Extract—A Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants. J Clin Med. 2021; 10(16): 3644. 24Dongre S, Langade D, Bhattacharyya S. Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study. Biomed Res Int. 2015;2015:284154.
  • Rhodiola – This is another adaptogenic herb that has been shown to increase physical endurance and productivity, help reduce fatigue and moodiness, and promote sexual health.25Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue–a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine. 2000 Oct;7(5):365-71. 26Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine. 2000 Apr;7(2):85-9. 27Shevtsov VA, Zholus BI, Shervarly VI, Vol’skij VB, Korovin YP, Khristich MP, Roslyakova NA, Wikman G. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine. 2003 Mar;10(2-3):95-105.
  • Saffron Extract – This herb helps protect the brain against oxidative damage and neurotoxicity while promoting a healthy mood in multiple studies.28Khazdair MR, Boskabady MH, Hosseini M, Rezaee R, Tsatsakis AM. The effects of Crocus sativus (saffron) and its constituents on nervous system: A review. Avicenna J Phytomed. 2015 Sep-Oct; 5(5): 376–391. 29Is Safr’Inside™ efficient on mood in only 15 days? Proprietary consumer study. Customer Technical Support. CTS-0138. Active Inside. Update 01 from 03/05/2018. Elaboration date 18/10/2017: 2 pgs. 30Akhondzadeh S Tahmacebi-Pour N, Noorbala AA, Amini H, Fallah-Pour H, Jamshidi AH, Khani M. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother Res. 2005 Feb;19(2):148-51. 31Modabbernia A, Sohrabi H, Nasehi AA, Raisi F, Saroukhani S, Jamshidi A, Tabrizi M, Ashrafi M, Akhondzadeh S. Effect of saffron on fluoxetine-induced sexual impairment in men: randomized double-blind placebo-controlled trial. Psychopharmacology (Berl). 2012 Oct;223(4):381-8. 32Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi F. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial [ISRCTN45683816]. BMC Complement Altern Med. 2004 Sep 2;4:12. 33Shahmansouri N, Farokhnia M, Abbasi SH, Kassaian SE, Noorbala Tafti AA, Gougol A, Yekehtaz H, Forghani S, Mahmoodian M, Saroukhani S, Arjmandi-Beglar A, Akhondzadeh S. A randomized, double-blind, clinical trial comparing the efficacy and safety of Crocus sativus L. with fluoxetine for improving mild to moderate depression in post percutaneous coronary intervention patients. J Affect Disord. 2014 Feb;155:216-22.
  • L-Theanine – Various studies have examined the effects of this amino acid on stress and anxiety34Kimura K, Ozeki M, Juneja LR, Ohira H. L-Theanine reduces psychological and physiological stress responses. Biol Psychol 2007;74(1):39-45 35Unno K, Tanida N, Ishii N, et al. Anti-stress effect of theanine on students during pharmacy practice: positive correlation among salivary α-amylase activity, trait anxiety and subjective stress. Pharmacol Biochem Behav. 2013 Oct;111:128-35. 36Yoto A, Motoki M, Murao S, Yokogoshi H. Effects of L-theanine or caffeine intake on changes in blood pressure under physical and psychological stresses. J Physiol Anthropol. 2012 Oct 29;31:28. 37Higashyama A, Htay HH, Ozeki M, Juneja LR, Kapoor MP. Effects of l-theanine on attention and reaction time response. Journal of Functional Foods. 2011;3(3):171–178., demonstrating its effectiveness in reducing in physiological indicators of stress within 15 minutes, reductions in heart rate, inhibition of cortical neuron excitation, suppressing the initial stress response, and significantly reducing stress-induced anxiety.
  • L-Tryptophan – Not only is this amino acid used by the body to produce the neurotransmitter serotonin (which plays a role in stress adaptation)38Chaouloff F, Berton O, Mormède P. Serotonin and Stress. Neuropsychopharmacol. 1999; 21(Suppl 1):28–32. https://doi.org/10.1016/S0893-133X(99)00008-1., but supplementation has been shown to result in fewer feelings of occasional anxiety39Lindseth G, Helland B, Caspers J. The effects of dietary tryptophan on affective disorders. Arch Psychiatr Nurs. 2015;29(2):102-107. doi:10.1016/j.apnu.2014.11.008 and a healthy mood.40Levitan RD, Shen J-H, Jindal R, Driver HS, Kennedy SH, Shapiro CM. Preliminary randomized double-blind placebo controlled trial of tryptophan combined with fluoxetine to treat major depressive disorder: antidepressant and hypnotic effects. J Psychiatry Neurosci 2000; 25(4):337-46. 41Lambert GW, Reid C, Kaye DM, Jennings GL, Esler MD. Effect of sunlight and season on serotonin turnover in the brain. Lancet 2002; 360(9348):1840-2.
  • B Vitamins – These vitamins are involved in the function of the nervous system42Whitney E, Rolfes S. Understanding Nutrition, Ninth Edition, Belmont, CA: Wadsworth/Thomson Learning; 2002. and play a role in helping to counter some of the negative effects of stress. Research on B-complex vitamins has demonstrated that their use has been able to improve measures of stress, vigor, tiredness, everyday mood including fatigue, and cognitive performance during intense mental processing.43Kennedy DO, Veasey R, Watson A, Dodd F, Jones E, Maggini S, Haskell CF. Effects of high-dose B vitamin complex with vitamin C and minerals on subjective mood and performance in healthy males. Psychopharmacology (Berl). 2010 Jul;211(1):55-68. 44Schlebusch L, Bosch BA, Polglase G, Kleinschmidt I, Pillay BJ, Cassimjee MH. A double-blind, placebo-controlled, double-centre study of the effects of an oral multivitamin-mineral combination on stress. S Afr Med J. 2000 Dec;90(12):1216-23. 45Carroll D, Ring C, Suter M, Willemsen G. The effects of an oral multivitamin combination with calcium, magnesium, and zinc on psychological well-being in healthy young male volunteers: a double-blind placebo-controlled trial. Psychopharmacology (Berl). 2000 Jun;150(2):220-5. 46Scholey A, Bauer I, Neale C, et al. Acute effects of different multivitamin mineral preparations with and without Guaraná on mood, cognitive performance and functional brain activation. Nutrients. 2013 Sep 13;5(9):3589-604.
  • Magnesium – This mineral is important for maintaining healthy nerve and muscle function47Wester PO. “Magnesium.” Am J Clin Nutr. 1987;45:1305-12., promoting muscle relaxation and reducing feelings of stress-related anxiety48Raman R. What does magnesium do for your body? Healthline. July 14, 2023.. Research suggests that it may help reduce certain reactions to stress49Muir KW, Lees KR. “Dose optimization of intravenous magnesium sulfate after acute stroke.” Stroke. 1998;29:918-23., as well as reducing overall feelings of stress.50Song Y et al. “Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women.” Diabetes Care. 2004;27:59-65. 51Larsson SC, Wolk A. “Magnesium intake and risk of type-2 diabetes: a meta-analysis.” J Intern Med. 2007:262:208-14.

 

Gut Health Supplements

Gut health and healthy digestion are vital to maintaining internal comfort and a sense of well-being. Consider that components of the gut microbiome play profound roles in gut health, including functioning as part of the digestive system, energy recovery from the metabolism of non-digestible components of foods, protection of a host from pathogenic invasion, and modulation of the immune system.52Bull MJ, Plummer NT. Part 1: The Human Gut Microbiome in Health and Disease. Integr Med (Encinitas). 2014;13(6):17-22.

The National Institute of Environmental Health Sciences states, “Differences in the microbiome may lead to different health effects from environmental exposures and may also help determine individual susceptibility to certain illnesses.”53Microbiome. The National Institute of Environmental Health Sciences. Last Reviewed: March 22, 2024. Retrieved June 21, 2024 from https://www.niehs.nih.gov/health/topics/science/microbiome#:~:text=Introduction,to%20human%20health%20and%20wellness.

Additionally, dietary patterns shift in the fall, with people consuming heavier foods and increasing their intake of total fat and saturated fat.54Ma Y, Olendzki BC, Li W, Hafner AR, Chiriboga D, Hebert JR, Campbell M, Sarnie M, Ockene IS. Seasonal variation in food intake, physical activity, and body weight in a predominantly overweight population. Eur J Clin Nutr. 2006 Apr;60(4):519-28. doi: 10.1038/sj.ejcn.1602346. PMID: 16340952; PMCID: PMC1428793. Since saturated fats are harder to digest than other fats and can be hard on the digestive system55Santos-Longhurst A. How Are Fats Digested, and Can You Speed Up the Process? Healthline. Updated April 13, 2023. Retrieved January 28, 2025 from https://www.healthline.com/health/fat-digestion., this means the gut must work harder in the fall.

Therefore, trends in supplements for gut health tend to rise during the fall months. These trends include probiotics, prebiotics, postbiotics, and a combination of two or more of these known as synbiotics, as well as fiber supplements and digestive enzymes.

  • Probiotics – These friendly bacteria, such as Lactobacillus acidophilus and Bifidobacterium longum, are defined as “live microorganisms that, when administered in adequate amounts, confer a health benefit on the host.”56Probiotics. ISAPP. Retrieved June 19, 2024 from https://isappscience.org/for-consumers/learn/probiotics/. They promote digestion and gut health. The probiotics market size is expected to reach $213.1 billion by 2032, growing at a CAGR of 12.4% from 2023 to 2032.57Acumen Research and Consulting. Probiotics Market is forecasted to Reach USD 213.1 Billion by 2032, growing at a 12.4% CAGR from 2023 to 2032. GlobeNewswire. October 5, 2023. https://www.globenewswire.com/news-release/2023/10/06/2755864/0/en/Probiotics-Market-is-forecasted-to-Reach-USD-213-1-Billion-by-2032-growing-at-a-12-4-CAGR-from-2023-to-2032.html
  • Prebiotics – Prebiotics are typically types of fiber, such as fructooligosaccharides (FOS) and galactooligosaccharides (GOS), that serve as food for beneficial probiotic bacteria in the gut. By nourishing these bacteria, prebiotics help stimulate their growth and activity, supporting overall gut health.58Prebiotics. ISAPP. Retrieved June 19, 2024 from https://isappscience.org/for-consumers/learn/prebiotics/ The global prebiotics market was projected to reach a valuation of $6.67 billion by 2023, recording a CAGR of 6.3% from 2023 to 2033.59Prebiotic Fiber Market. Future Market Insights. Retrieved June 21, 2024 from https://www.futuremarketinsights.com/reports/prebiotic-fiber-market.
  • Postbiotics – A postbiotic can be any probiotic that has been pasteurized or heat-treated, such as Akkermansium mucinipahila and Lactobacillus plantarum L-137, yet still provides health benefits—a sort of zombie probiotic if you will. Although a postbiotic is not a live organism, it still provides probiotic-like effects including a range of gut health activities.60Postbiotics: debate continues and the ISAPP definition gains support. ISAPP. Retrieved June 19, 2024 from https://isappscience.org/postbiotics-debate-continues-and-the-isapp-definition-gains-support/. The global postbiotic supplements market was estimated to be valued at $10.8 million in 202461Postbiotic Supplements Market. Future Market Insights, Inc. Retrieved June 21, 2024 from https://www.futuremarketinsights.com/reports/postbiotic-supplements-market., and is expected to reach $30.5 million by 2034 at a CAGR of 10.9%.
  • Synbiotics – Synbiotics (i.e., synergistic biotics) are a biotics combination, typically pre-and probiotics, but may include postbiotics as well. A symbiotic combination makes sense on a couple of levels. First, prebiotics feed and nurture probiotics, so there is a good rationale for the combination of the two. Now that postbiotics are available, a combination of all three makes for a comprehensive approach to supporting the health of the microbiome with the three categories of biotics.
  • Fiber Supplements – Dietary fiber sources can help relieve occasional constipation and promote regularity62Food and Nutrition Board, Institute of Medicine. Dietary, Functional, and Total Fiber. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, D.C.: National Academy Press; 2005:370.. As an added benefit, some fibers like acacia gum can also help increase levels of healthy bifidobacteria and lactobacilli in the intestinal tract.63Cherbut C, Michel C, Raison V, Kravtchenko TP, Meance S. Acacia Gum is a bifidogenic dietary fiber with high digestive tolerance in healthy humans. Microbial Ecol Health Dis. 2003; 15:43–50. The fiber supplements market was valued at $13.7 Billion in 2023 and is expected to reach about $19.42 billion by 2030 at a CAGR of 5.11%.64Fiber Supplements Market: Cutting-Edge Innovations and Strategic Shifts in a Dynamic Industry. MMR. Retrieved January 28, 2025 from https://www.maximizemarketresearch.com/market-report/fiber-supplements-market/266946/#:~:text=The%20Fiber%20Supplements%20Market%20was,USD%2019.42%20Billion%20by%202030.
  • Digestive Enzymes – Proteases, lipases, and amylases are digestive enzymes shown to help compensate for reduced enzyme production, thereby improving overall digestive capacity.65Alternative Medicine, the Definitive Guide. Future Medicine Publishing: Puyallup, WA. 1993;215-22. 66Griffin SM, et al. Acid resistant lipase as replacement therapy in chronic pancreatic exocrine insufficiency: a study in dogs. Gut 1989;30:1012-15. Such enzymes are available from vegan sources, as well as from pancreatic sources. The digestive enzyme supplement market size was valued at about $3.7 billion in 2024 and is expected to grow to $4.3 Billion by 2032 at a CAGR of 1.9%.67Digestive Enzyme Supplement Market Insights. Skyquest. Retrieved January 28, 2025 from https://www.skyquestt.com/report/digestive-enzyme-supplement-market#:~:text=Digestive%20Enzyme%20Supplement%20Market%20size%20was%20valued%20at%20USD%203.63,period%20(2025%2D2032).

If you’re planning to introduce a probiotic product to the market, be sure to partner with probiotic supplement manufacturers who have proven experience formulating these specialized products.

 

Nutricosmetics Supplements

Cooler temperatures and lower humidity make fall a challenging season for skin and hair. Skin tends to become drier, leading to increased flakiness and itchiness, while hair can become more brittle and frizzier due to the lack of moisture in the air.68Seasonal Beauty Tips for Fall. Shore Beauty School. Retrieved January 28, 2025 from https://shorebeautyschool.edu/seasonal-beauty-tips-for-fall/#:~:text=Nourish%20Your%20Hair,blow%20dryers%20and%20flat%20irons. This drives nutritional supplement industry trends toward increased interest in nutricosmetics—nutraceuticals that support the natural beauty of skin, hair, and nails from within.69Dini I, Laneri S. Nutricosmetics: A brief overview. Phytother Res. 2019;33(12):3054-3063. doi:10.1002/ptr.6494

As a supplement category, it is often referred to as “beauty from within” or simply beauty supplements. The global beauty supplement market size was valued at $3.3 billion in 2024, and it is expected to reach $8.5 billion in 2034 with a CAGR of 9.6% during the forecast period.70Beauty Supplement Market Size. Global Market Insights. Retrieved January 28, 2025 from https://www.gminsights.com/industry-analysis/beauty-supplement-market. Consequently, you’ll want to consider expanding into this category for your fall 2025 product lineup.

Also, keep in mind that there is an overlap in the “beauty from within” and “anti-aging” (or healthy aging) categories. After all, a change in the appearance of skin and hair is the most obvious outward sign of aging. In part, this is due to a decline in collagen levels which increases fine lines and wrinkles, decreases skin elasticity, and sometimes results in drier skin. Also, hair growth and thickness begin declining and there is often an increase in hair shedding. In these instances, the use of the nutraceuticals previously discussed may help to slow down these signs of skin and hair aging and generally help promote healthier-looking skin, hair, and nails during the fall.

Skin Health Nutraceuticals

  • Collagen – The size of the global collagen market in 2022 was $10.08 billion and was forecasted to reach approximately $23.02 billion by 2032 with a CAGR of 8.9%.71Collagen Market (By Source: Bovine, Marine, Porcine, Poultry; By Product: Gelatin, Hydrolyzed collagen, Native collagen, Synthetic collagen; By Application: Food and Beverage, Healthcare, Pharmaceuticals, Nutraceuticals, Cosmetics, Others; By Type; By Form; By Product Category; By Function) – Global Industry Analysis, Size, Share, Growth, Trends, Regional Outlook, and Forecast 2023 – 2032. Precedence Research. Retrieved January 27, 2024 from https://www.precedenceresearch.com/collagen-market#:~:text=The%20global%20collagen%20market%20size,forecast%20period%202023%20to%202032. Collagen is arguably the most popular of all the skin health nutraceuticals. Two specific sources of collagens, grass-fed (bovine source) and marine collagen (fish source) are showing strong 10-year growth projections of $113.1 million to $279.6 million (CAGR of 8.6%)72Grass-fed Collagen Market. Fact.MR. Retrieved September 24, 2024 from https://www.factmr.com/report/grass-fed-collagen-market. and $1.07 billion to $2.32 billion (CAGR of 8.0%)73Marine Collagen Ingredients Market. Fact.MR. Retrieved September 24, 2024 from https://www.factmr.com/report/marine-collagen-ingredients-market., respectively. Both sources have strong human research demonstrating effectiveness:
      • Bovine Collagen Peptides – Highly bioavailable74Schunck M, Zague V, Oesser S, Proksch E. Dietary Supplementation with Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology. J Med Food. 2015 Dec;18(12):1340-8., this type of collagen has been shown75Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27(3):113-9. to support and stimulate the body’s own collagen production, increasing pro-collagen production by 65%, and increasing production of the critical skin protein elastin by 18%. Likewise, studies76Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27(3):113-9. 77Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. 78Proksch E, Schunck M, Zague V, Segger D, Degwert J, Oesser S. Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol Physiol. 2014;27(3):113-9. 79Oesser S. The oral intake of specific Bioactive Collagen Peptides has a positive effect on hair thickness. Nutrafoods (2020) 1:134-138. have demonstrated that it has significantly reduced wrinkles, improved skin elasticity and moisture, reduced cellulite, and increased hair thickness.
      • Marine Collagen Peptides – Research80Dutein L, Roussel CQ, Bruno-Bonnet C, Lacour JP. Effect of Low Dose Type I Fish Collagen Peptides Combined or not with Silicon on Skin Aging Signs in Mature Women. JOJ Case Stud. 2018;6(4) ID.555692. 81Fish collagen peptides for skin beauty: Anti-aging benefits of collagen. AIDP. Unpublished. n.d. 2 pgs. 82Evans M, Lewis ED, Zakaria N, Pelipyagina T, Guthrie N. A randomized, triple-blind, placebo-controlled, parallel study to evaluate the efficacy of a freshwater marine collagen on skin wrinkles and elasticity. J Cosmet Dermatol. 2021;20(3):825-834. doi:10.1111/jocd.13676. has demonstrated that marine collagen peptides reduced wrinkles, improved skin elasticity, maintained skin firmness, and improved skin tone and radiance while improving skin moisture. Other research83Duteil L, Queille-Roussel C, Maubert Y, et al. SPECIFIC NATURAL BIOACTIVE TYPE 1 COLLAGEN PEPTIDES ORAL INTAKE REVERSE SKIN AGING SIGNS IN MATURE WOMEN. J Aging Res Clin Practice 2016;5(2):84-92. confirms that marine collagen peptides improved skin elasticity, reduced crows-feet wrinkles, and promoted skin firmness.
  • Ceramides – Ceramides play a key role in the skin’s barrier function. Supplementation studies84Bizot V, Cestone E, Michelotti A, Nobile V. Improving Skin Hydration and Age-related Symptoms by Oral Administration of Wheat Glucosylceramides and Digalactosyl Diglycerides: A Human Clinical Study. Cosmetics. 2017; 4:37. have shown improvements in skin Moisturization Index, reduced transepidermal water loss, increased skin elasticity, reduced skin wrinkles, improved skin smoothness and reduced skin roughness.
  • Hyaluronic Acid – Hyaluronic acid is present in skin and other connective tissue where it binds to water to help maintain hydration. In a supplementation study, it was found to increase skin moisture content and reduce wrinkles.85Hsu TF, Su ZR, Hsieh YH, Wang MF, Oe M, Matsuoka R, Masuda Y. Oral Hyaluronan Relieves Wrinkles and Improves Dry Skin: A 12-Week Double-Blinded, Placebo-Controlled Study. Nutrients. 2021 Jun 28;13(7):2220. doi: 10.3390/nu13072220. PMID: 34203487; PMCID: PMC8308347.
  • Astaxanthin – Human studies86Tsukahara H, Matsuyama A, ABE T, et al. Effects of Intake of Astaxanthin Contained Drink on Skin Condition. Jpn J Complem Altern Med. 2016;13(2):57-62 87Yamashita E. The Effects of a Dietary Supplement Containing Astaxanthin on Skin Condition. Carotenoid Science. 2006;10:91-95. have shown that this powerful antioxidant suppressed damage to skin barrier function, alleviated skin dryness by preserving the water-retention capacity of the skin, improved skin viscoelasticity and texture, significantly reduced the appearance of fine lines and wrinkles, improved the moisture content of dry skin, while supporting a shift toward characteristics of skin associated with a younger age and producing a strong antioxidant effect supporting facial skin rejuvenation.88Chalyk NE, Klochkov VA, Bandaletova TY, Kyle NH, Petyaev IM. Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers. Nutr Res. 2017 Dec;48:40-48.
  • Blood Orange Extract – Research has demonstrated that blood orange extract helped reduce UV-induced age spots and skin redness89Puglia C, Offerta A, Saija A, Trombetta D, Venera C. Protective effect of red orange extract supplementation against UV-induced skin damages: photoaging and solar lentigines. J Cosmet Dermatol. 2014 Jun;13(2):151-7., while providing meaningful antioxidant properties.90Bonina FP, Leotta C, Scalia G, Puglia C, et al. Evaluation of oxidative stress in diabetic patients after supplementation with a standardized red-orange extract. Diabetes Nutr Metab. 2002 Feb;15(1):14-9.
  • Grapeseed Extract – Grape seed extract has been clinically tested to help reduce hyperpigmentation.91Yamakoshi J, Sano A, Tokutake S, Saito M, Kikuchi M, Kubota Y, Kawachi Y, Otsuka F. Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma. Phytother Res. 2004 Nov;18(11):895-9.
  • Zinc – Helps improve non-cystic acne in clinical research92Meynadier J. Efficacy and safety study of two zinc gluconate regimens in the treatment of inflammatory acne. Eur J Dermatol 2000;10:269-73. 93Dreno B, Amblard P, Agache P, Sirot S, Litoux P. Low doses of zinc gluconate for inflammatory acne. Acta Derm Venereol 1989;69(6):541-3. 94Dreno B, Moyse D, Alirezai M, et al. Multicenter randomized comparative double-blind controlled clinical trial of the safety and efficacy of zinc gluconate versus minocycline hydrochloride in the treatment of inflammatory acne vulgaris. Dermatology. 2001;203(2):135-40. 95Goransson K, Liden S, Odsell L. Oral zinc in acne vulgaris: a clinical and methodological study. Acta Derm Venereol 1978;58:443-8. 96Hillstrom L, Pettersson L, Hellbe L, et al. Comparison of oral treatment with zinc sulphate and placebo in acne vulgaris. Br J Dermatol 1977;97:681-4. 97Verma KC, Saini AS, Dhamija SK. Oral zinc sulphate therapy in acne vulgaris: a double-blind trial. Acta Derm Venereol. 1980;60(4):337-40., likely due to the fact that people with acne have lower levels of zinc.98Kaymak Y, Adişen E, Erhan M, et al. Zinc Levels in Patients with Acne Vulgaris. J Turk Acad Dermatol. 2007;1(3):71302a 99Amer M, Bahgat MR, Tosson Z, et al. Serum zinc in acne vulgaris. Int J Dermatol 1982;21:481-4. 100Michaelsson G, Vahlquist A, Juhlin L. Serum zinc and retinol-binding protein in acne. Br J Dermatol 1977;96:283-6. 101Michaelsson G, Ljunghall K. Patients with dermatitis herpetiformis, acne, psoriasis and Darier’s disease have low epidermal zinc concentrations. Acta Derm Venereol 1990;70:304-8.

Hair Health Nutraceuticals

  • Biotin – If you have a biotin deficiency resulting in hair loss102Zempleni J, et al. Expert Rev Endocrinol Metab 2008;3(6):715–724., biotin supplementation may help. It is unlikely that biotin supplementation alone will otherwise impact hair growth103Soleymani T, et al. J Drugs Dermatol. 2017 May 1;16(5):496-500., although it may have value when combined with keratin.104Beer C, Wood S, Veghte RH. A Clinical Trial to Investigate the Effect of Cynatine HNS on Hair and Nail Parameters.The Scientific World Journal. 2014; 2014, Article ID 641723:6 pgs.
  • Spermidine – This polyamine compound promotes hair shaft elongation and upregulated expression of the epithelial stem cell-associated keratins.105Ramot Y, Tiede S, Bíró T, Abu Bakar MH, Sugawara K, Philpott MP, Harrison W, Pietilä M, Paus R. Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. PLoS One. 2011;6(7):e22564. Human clinical studies106Rinaldi F, Sorbellini E, Bezzola P, Marchioretto DI. Biogenina® based food supplement: hair growth enhancer. NutraFood. 2003;2:1-7. 107Rinaldi F, Marzani B, Pinto D, Ramot Y. A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study. Dermatol Pract Concept. 2017 Oct 31;7(4):17-21. showed that supplementation with spermidine supported the anagen phase of hair growth, reduced hair shedding, and promoted hair thickness.
  • Pomegranate Extract – Human clinical research108Randomized clinical trial to evaluate the healthy properties and tolerability of two treatments for the prevention of hair loss in people with non-scarring alopecia. Strictly confidential. Unpublished. Euromed. found that a pomegranate extract helped reduce hair shedding while promoting hair growth and hair thickness.
  • Solubilized Keratin – Research109Kelly R, Gu J, Lim J, Lati E, Manna V. Effect of keraGEN IV Keratin oral supplementation on hair, skin, and nail attributes. HealthMED. 2024; 18(2):35-45. on supplementation with solubilized keratin resulted in improved hair structure and reduction in hair loss, as well as in improvement in skin structure.

 

Women’s Health Supplements

The size of the women’s health supplements was valued at $41.1 billion in 2023 and is expected to reach $66.5 billion by 2032, growing at a CAGR of 5.6%.110Women’s Health Supplements Market Size. Global Market Insights. Retrieved March 14, 2025 from https://www.gminsights.com/industry-analysis/womens-health-supplements-market. Within this trending category, there are several subcategories. These include, but are not limited to menopause, fertility, longevity, and metabolic health.

  • Menopause – This natural transition in the life of women is associated with a reduction in estrogen production, cessation of menstruation, and some transitory symptoms such as hot flashes, night sweats, and mood swings. Some nutraceuticals which have been shown to help reduce these symptoms include the following. Pueraria mirifica root extract, a natural phytoestrogen, works by binding to estrogen receptors. It was demonstrated to significantly reduce hot flashes, night sweats, nervousness, and vaginal dryness.111Manonai J, Chittacharoen A, Theppisai U, Theppisai H. Effect of Pueraria mirifica on vaginal health. Menopause. 2007 Sep-Oct;14(5):919-24. 112Okamura S, Sawada Y, Satoh T, Sakamoto H, Saito Y, Sumino H, Takizawa T, Kogure T, Chaichantipyuth C, Higuchi Y, Ishikawa T, Sakamaki T. Pueraria mirifica phytoestrogens improve dyslipidemia in postmenopausal women probably by activating estrogen receptor subtypes. Tohoku J Exp Med. 2008 Dec;216(4):341-51. 113Chandeying V, Sangthawan M. Efficacy Comparison of Pueraria mirifica (PM) against Conjugated Equine Estrogen (CEE) with/without Medroxyprogesterone Acetate (MPA) in the Treatment of Climacteric Symptoms in Perimenopausal Women: Phase III Study. J Med Assoc Thai 2007; 90 (9): 1720-6 114Virojchaiwong P, Suvithayasiri V, Itharat A. Comparison of Pueraria mirifica 25 and 50 mg for menopausal symptoms. Arch Gynecol Obstet. 2011 Aug;284(2):411-9. 115Lamlertkittikul S, Chandeying V. Efficacy and safety of Pueraria mirifica (Kwao Kruea Khao) for the treatment of vasomotor symptoms in perimenopausal women: Phase II Study. J Med Assoc Thai. 2004 Jan;87(1):33-40. 116Chandeying V, Lamlertkittikul S. Challenges in the Conduct of Thai Herbal Scientific Study: Efficacy and Safety of Phytoestrogen, Pueraria Mirifica (Kwao Keur Kao), Phase I, in the Alleviation of Climacteric Symptoms in Perimenopausal Women. J Med Assoc Thai 2007; 90 (7):1274-80. Black cohosh root extract, which is probably the best-known menopause support herb, has likewise been shown to relieve these same symptoms, as well as moodiness and sleeplessness.117Ross SM. Menopause: a standardized isopropanolic black cohosh extract (remifemin) is found to be safe and effective for menopausal symptoms. Holist Nurs Pract. 2012 Jan-Feb;26(1):58-61. 118Osmers R, Friede M, Liske E, Schnitker J, Freudenstein J, Henneicke-von Zepelin HH. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet Gynecol. 2005;105(5 Pt 1):1074-83. 119Frei-Kleiner S, Schaffner W, Rahlfs VW, Bodmer Ch, Birkhäuser M. Cimicifuga racemosa dried ethanolic extract in menopausal disorders: a double-blind placebo-controlled clinical trial. Maturitas. 2005;51(4):397-404. 120Wuttke W, Seidlová-Wuttke D, Gorkow C. The Cimicifuga preparation BNO 1055 vs. conjugated estrogens in a double-blind placebo-controlled study: effects on menopause symptoms and bone markers. Maturitas. 2003;44 Suppl 1:S67-77. 121Stoll W. Phytopharmacon influences atrophic vaginal epithelium: double blind study – cimicifuga vs. estrogenic substances. Source: Therapeutikum. 1987;1:23-31. Rheum rhaponticum root extract (a.k.a., Rhapontic Rhubarb), was able to relieve many of these same symptoms, but also helped promote urinary function and sexual function. 122Heger M, Ventskovskiy BM, Borzenko I, Kneis KC, Rettenberger R, Kaszkin-Bettag M, Heger PW. Efficacy and safety of a special extract of Rheum rhaponticum (ERr 731) in perimenopausal women with climacteric complaints: a 12-week randomized, double-blind, placebo-controlled trial. Menopause. 2006 Sep-Oct;13(5):744-59. 123Kaszkin-Bettag M, Ventskovskiy BM, Solskyy S, Beck S, Hasper I, Kravchenko A, Rettenberger R, Richardson A, Heger PW. Confirmation of the efficacy of ERr 731 in perimenopausal women with menopausal symptoms. Altern Ther Health Med. 2009 Jan-Feb;15(1):24-34. 124Hasper I, Ventskovskiy BM, Rettenberger R, Heger PW, Riley DS, Kaszkin-Bettag M. Long-term efficacy and safety of the special extract ERr 731 of Rheum rhaponticum in perimenopausal women with menopausal symptoms. Menopause. 2009 Jan-Feb;16(1):117-31. 125Kaszkin-Bettag M, Beck S, Richardson A, Heger PW, Beer AM. Efficacy of the special extract ERr 731 from rhapontic rhubarb for menopausal complaints: a 6-month open observational study. Altern Ther Health Med. 2008 Nov-Dec;14(6):32-8. 126Kaszkin-Bettag M, Ventskovskiy BM, Kravchenko A, Rettenberger R, Richardson A, Heger PW, Heger M. The special extract ERr 731 of the roots of Rheum rhaponticum decreases anxiety and improves health state and general well-being in perimenopausal women. Menopause. 2007 Mar-Apr;14(2):270-83.
  • Fertility –One of the nutraceuticals with benefit for this purpose is maca root, whose fertility-enhancing properties were first described in 1653.127Gonzales GF. Ethnobiology and Ethnopharmacology of Lepidium meyenii (Maca), a Plant from the Peruvian Highlands. Evid Based Complement Alternat Med. 2012; 2012: 193496. Another nutraceutical with good research is vitamin D. In fact, multiple human studies128Meng X, Zhang J, Wan Q, et al. Influence of vitamin D supplementation on reproductive outcomes of infertile patients: a systematic review and meta-analysis. Reprod Biol Endocrinol 2023;21(1):17. have demonstrated that supplementation with vitamin D increased the odds of clinical pregnancy by 49% compared with taking a placebo. Other research129Zhou X, Wu X, Luo X, et al. Effect of Vitamin D Supplementation on In Vitro Fertilization Outcomes: A Trial Sequential Meta-Analysis of 5 Randomized Controlled Trials. Front Endocrinol (Lausanne) 2022;13:852428.  has shown similar effects.
  • Longevity – There are many factors associated with promoting a healthy lifespan. One such factor is NAD, an important coenzyme in the body involved in energy metabolism, and multiple biochemical processes in the body. NAD production decreases with age, a process linked to key hallmarks of aging. However, research suggests that increasing NAD levels may slow aspects of aging.130Aman Y, Qiu Y, Tao J, Fang EF. Therapeutic potential of boosting NAD+ in aging and age-related diseases. Translational Medicine of Aging. 2018; 2:30-37 NAD precursors that have been shown to help increase NAD production include NMN (nicotinamide mononucleotide), NR (nicotinamide riboside) and niacinamide.131Ito TK, Sato T, Hakamata A, et al. A nonrandomized study of single oral supplementation within the daily tolerable upper level of nicotinamide affects blood nicotinamide and NAD+ levels in healthy subjects. Translational Medicine of Aging. 2020; 4:45-54. Another factor is autophagy, the body’s process of breaking down old and damaged cell parts, repurposing the salvageable components into new, usable cell parts while discarding the unusable or unneeded parts. A rice germ extract standardized for its spermidine contact has been shown in human clinical research132La Monica M, Ziegenfuss TN. Effects of Spermidine Supplementation on Biomarkers of Healthy Aging and Autophagy. Biostatistical and Clinical Study Report. The Center for Applied Health Sciences. January 3, 2025. 71 pgs (unpublished). to increase markers of autophagy.
  • Metabolic Health – Metabolic health refers to helping promote healthy glucose, insulin, and blood lipid levels. Numerous nutraceuticals have been shown to promote metabolic health. In human research133Usharani P, Fatima N, Muralidhar N. Effects of Phyllanthus emblica extract on endothelial dysfunction and biomarkers of oxidative stress in patients with type 2 diabetes mellitus: a randomized, double-blind, controlled study. Diabetes Metab Syndr Obes. 2013 Jul 26;6:275-84. 134Usharani P, Merugu PL, Nutalapati C. Evaluation of the effects of a standardized aqueous extract of Phyllanthus emblica fruits on endothelial dysfunction, oxidative stress, systemic inflammation and lipid profile in subjects with metabolic syndrome: a randomised, double blind, placebo controlled clinical study. BMC Complement Altern Med. 2019 May 6;19(1):97., Indian gooseberry (a.k.a., Alma) extract has been shown to promote healthy serum lipid and HbA1c (a marker for long-term glucose control) levels already in a normal range. Thymoquine, a natural compound derived from black seed oil, was also found to be effective in promoting healthy glucose levels already in a normal range.135Tavakoli-Rouzbehani OM, Abbasnezhad M, Kheirouri S, Alizadeh M. Effects of Nigella sativa oil supplementation on selected metabolic parameters and anthropometric indices in patients with coronary artery disease: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2021 Jul;35(7):3988-3999. 136Fallah Huseini H, Amini M, Mohtashami R, Ghamarchehre ME, Sadeqhi Z, Kianbakht S, Fallah Huseini A. Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2013 Dec;27(12):1849-53. 137Hadi S, Daryabeygi-Khotbehsara R, Mirmiran P, McVicar J, Hadi V, Soleimani D, Askari G. Effect of Nigella sativa oil extract on cardiometabolic risk factors in type 2 diabetes: A randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2021 Jul;35(7):3747-3755. Chromium is known to enhance the action of insulin, and supplementation with certain forms of chromium has been shown to promote healthy glucose, and serum lipid levels already in a normal range.138Bruno G. Chromium/Herbal Complex for Glucose & Cardiovascular Health. Vitamin Retailer. April 8, 2020. Retrieved March 14, 2025 from https://vitaminretailer.com/chromium-herbal-complex-for-glucose-cardiovascular-health/.

 

Joint and Inflammation Support

Colder temperatures, beginning in the fall and extending into winter, are linked to increased inflammation, which can exacerbate joint discomfort and other inflammatory conditions. In one study139Halonen JI, Zanobetti A, Sparrow D, Vokonas PS, Schwartz J. Associations between outdoor temperature and markers of inflammation: a cohort study. Environ Health. 2010 Jul 23;9:42., a 24.9% increase in an inflammatory marker (C-reactive protein) was seen for every 41-degree Fahrenheit decline.

The significance of this is that if you already have physical discomfort due to inflammation, such as joint inflammation due to physical overexertion140Suzuki K, Peake J, Nosaka K, et al. Changes in markers of muscle damage, inflammation and HSP70 after an Ironman Triathlon race. Eur J Appl Physiol. 2006 Dec;98(6):525-34. 141Rowlands DS, Pearce E, Aboud A, et al. Oxidative stress, inflammation, and muscle soreness in an 894-km relay trail run. Eur J Appl Physiol. 2012 May;112(5):1839-48., then that discomfort may worsen as the temperatures drop.

Consequently, the demand for supplements that support joint health and reduce inflammation in a healthy population may rise during the fall. This trend aligns with the significant growth of the global bone and joint health supplements market, which was valued at $3.90 billion in 2023 and is projected to grow at a CAGR of 7.26% by 2030.142Bone And Joint Health Supplements Maret Size, Share & Trends Analysis Report. Grand View Research. Retrieved May 23, 2024 from https://www.grandviewresearch.com/industry-analysis/bone-joint-health-supplements-market-report

Nutritional supplements industry trends for joint and inflammation support include:

  • Turmeric (Curcumin) – In human studies143Belcaro G, Cesarone MR, Dugall M, et al. Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med. 2010;52(2 Suppl 1):55-62. 144Drobnic F, Riera J, Appendino G, et al. Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): a randomised, placebo-controlled trial. J Int Soc Sports Nutr. 2014;11:31. Published 2014 Jun 18. doi:10.1186/1550-2783-11-31, well-absorbed turmeric extract was found to improve joint comfort, improve walking distance, promote joint function, and reduce inflammation (delayed onset muscle soreness) in association with overexercising.
  • Boswellia – Boswellia extract may help promote joint comfort in as early as 5 days and promote physical function in as little as 7 days.145Vishal AA, Mishra A, Raychaudhuri SP. A Double Blind, Randomized, Placebo Controlled Clinical Study Evaluates the Early Efficacy of Aflapin® in Subjects with Osteoarthritis of Knee. Int J Med Sci. 2011; 8(7): 615–622. 146Sengupta K, Krishnaraju AV, Vishal AA, Mishra A, Trimurtulu G, Sarma KV, Raychaudhuri SK, Raychaudhuri SP. Comparative efficacy and tolerability of 5-Loxin and Aflapin against osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study. Int J Med Sci. 2010 Nov 1;7(6):366-77.
  • Ginger – Ginger extract has been shown to promote joint comfort in general, when standing and after walking.147Altman RD, Marcussen KC. Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis Rheum. 2001;44(11):2531-2538. doi:10.1002/1529-0131(200111)44:11<2531::aid-art433>3.0.co;2-j
  • Cucumber Extract – Human clinical research148Nash RJ, Azantsa BK, Sharp H, Shanmugham V. Effectiveness of Cucumis sativus extract versus glucosamine-chondroitin in the management of moderate osteoarthritis: a randomized controlled trial. Clin Interv Aging. 2018 Oct 25;13:2119-2126. 149McFarlin BK. Modulating Exercise Recover with Curcumin, Boswellia, and IminoSugar: A Pilot Study. Applied Physiology Laboratory. University of North Texas. June 26, 2018. 150Pérez-Piñero S, Muñoz-Carrillo JC, Victoria-Montesinos D, García-Muñoz AM, Ávila-Gandía V, López-Román FJ. Effectiveness of a Cucumber Extract Supplement on Articular Pain in Patients with Knee Osteoarthritis: A Randomized Double-Blind Controlled Clinical Trial. Applied Sciences. 2023; 13(1):485. has demonstrated that a cucumber extract promotes joint comfort, maintains healthy joint function, reduces exercise-related muscle soreness, improves muscle strength recovery associated with exercise, and has an anti-inflammatory effect in association with overexercising.
  • Water-Soluble Eggshell Membrane (WSEM) – In a healthy human population, a study151Jensen GS, Lenninger MR, Beaman JL, Taylor R, Benson KF. Support of Joint Function, Range of Motion, and Physical Activity Levels by Consumption of a Water-Soluble Egg Membrane Hydrolyzate. J Med Food. 2015 Sep;18(9):1042-8. demonstrated that WSEM improved the range of motion for the neck, spine, hips, and knees, improved physical activity levels, and promoted back comfort.
  • Type 2 Collagen – In a study152Lopez HL, Ziegenfuss TN, Park J. Evaluation of the Effects of BioCell Collagen, a Novel Cartilage Extract, on Connective Tissue Support and Functional Recovery From Exercise. Integr Med (Encinitas). 2015 Jun;14(3):30-8. PMID: 26770145; PMCID: PMC4566464. with recreationally active individuals, type 2 collagen helped reduce inflammation in association with overexercising and promoted more robust muscular recovery.

 

Evidence-Based Ingredients

How important are evidence-based ingredients to consumers?

Well, data indicates that 59% of global consumers expect supplement efficacy to be supported by scientific evidence, and product claims are important to 50% of consumers. The bottom line is that consumers want dietary supplements to be safe and effective and supported by documented results.153Top 5 Drivers for Future Dietary Supplement Consumers. ADM. Retrieved January 29, 2025 from https://www.adm.com/en-us/news/adm-stories/top-5-drivers-for-the-dietary-supplement-consumer-of-tomorrow/#:~:text=Globally%2C%2059%25%20of%20consumers%20expect,and%20supported%20by%20documented%20results.

Therefore, the answer to the question is, “Very important!”.

Now, consider that a survey154Karbownik MS, Paul E, Nowicka M, et al. Knowledge about dietary supplements and trust in advertising them: Development and validation of the questionnaires and preliminary results of the association between the constructs. PLoS One. 2019;14(6):e0218398. Published 2019 Jun 24. doi:10.1371/journal.pone.0218398 assessed consumer knowledge about and trust in dietary supplements. The results found both the knowledge about dietary supplements in the study group and trust in advertising them were low. A significant negative relationship was found between knowledge about dietary supplements and trust in advertising them among the general public.

Collectively, this makes a great case for utilizing evidence-based ingredients in your dietary supplement formulas. A good contract development and manufacturing organization (CDMO) can help you identify and choose appropriate ingredients to substantiate desired claims.

 

Bioavailable and Enhanced Absorption Formulations

Some nutraceuticals have reasonably good absorption and bioavailability, while others do not.

For example, research shows that the absolute bioavailability of resveratrol is about 1%.155Bruno G. SNEDS: The Ultimate Delivery System for Nutraceuticals. Vitamin Retailer. July 2024:37-40. This is often due to extensive first-pass metabolism in the liver, where much of the nutraceutical may be metabolized into inactive forms or excreted before reaching systemic circulation.

According to Nutrition Insight156Marketing bioavailability: “Aware” consumers are pushing companies to innovate. Nutrition Insight. 05 Mar 2019. Retrieved January 29, 2025 from https://www.nutritioninsight.com/news/marketing-bioavailability-aware-consumers-are-pushing-companies-to-innovate.html., some consumers are aware of bioavailability and are demanding more information about it. There are a few evidence-based technologies for improving absorption and bioavailability for select nutraceuticals. These include:

  • Microencapsulation – Enrobing active nutraceuticals in clean-label materials can provide protection to the active and improve its delivery in the gastrointestinal tract.
  • Agglomeration – This is the process of joining particles together to form larger, more cohesive pieces. Agglomeration can affect nutrient absorption by changing the physical properties of particles, such as their size, density, and porosity.157Müller KH, Motskin M, Philpott AJ, et al. The effect of particle agglomeration on the formation of a surface-connected compartment induced by hydroxyapatite nanoparticles in human monocyte-derived macrophages. Biomaterials. 2014; 35(3):1074-1088.

 

Multi-Functional Supplements

While consumers often choose their supplements based on a specific benefit they want to obtain, they also appreciate a multi-functional supplement that provides multiple benefits in addition to the one they originally wanted. An example is magnesium which has become a “holy grail” supplement due to its wide range of benefits, including sleep aid, mood improvement, and blood sugar regulation.158SPINS Marketing. Vitamins, Supplements, and Sports Nutrition: Key Trends Shaping 2024. August 27, 2024. SPINS. Retrieved January 29, 2025 from https://www.spins.com/resources/blog/vitamins-supplements-and-sports-nutrition-key-trends-shaping-2024/#:~:text=Magnesium%2C%20in%20particular%2C%20has%20become,long%2Dterm%20health%20and%20wellness.

Other examples include astaxanthin, with human clinical research showing benefits for cardiovascular health, muscle endurance, eye fatigue, dyspepsia, youthful skin aging, fat metabolism, stress and immune function159Bruno G. Research Update on the Many Uses of Astaxanthin. Vitamin Retailer. September 2020:58-81.; and resveratrol with human studies demonstrating effectiveness for cardiovascular health, inflammation, immune health, breast health, muscle health, cognitive health, weight loss, blood sugar/insulin resistance, and liver health.160Bruno G. Resveratrol: A Research Review. Total Health. June 2018: 12-17.

So, when formulating new products, keep ingredients like these in mind so that you can provide multi-functional supplements to customers.

 

Proactive Health and Preventive Supplements

It’s no surprise that consumers typically look for supplements to address their personal and specific health concerns—and that is not likely to change. What is changing, however, is that consumers are taking a more proactive role by prioritizing prevention, as indicated by the fact that this is the #3 trend in the Innova Market Insights Top 10 Trends 2024 survey.161Top 10 Trend Highlights Prioritizing Prevention. Innova Market Insights. June 7, 2024. Retrieved January 30, 2025 from https://www.innovamarketinsights.com/trends/top-10-trend/#:~:text=Consumers%20are%20turning%20to%20supplements,%2C%20elderberry%2C%20and%20sea%20moss. Product launches are now focusing on the ingredients that promote health and the proactive health benefits. Specific areas of interest include healthy aging, mental well-being, stress, anxiety, weight management, heart health, and joint and bone health.

In the aforementioned survey, consumers indicated that they are looking for proactive health benefits that are targeted to specific body functions. Each generation has different priorities. For Gen X, Millennials, and Gen Z, weight management is a top concern. For Boomers, it is heart health and weight management. Although heart health is the number two concern for Gen X and Millennials. Gen Z is mostly focused on skin health.

 

Personalized Supplements & Precision Wellness

Precision wellness and personalized supplements are flip sides of the same coin. Precision is a healthcare practice that uses data to create personalized plans to improve a person’s health. Personalized supplements are the result of using that data. In 2023, the Global Personalized Nutrition and Supplements Market was valued at $14.6 billion and is expected to reach $37.3 billion by 2032.162Personalized Nutrition and Supplements Industry Innovations, Market Trends and Future Growth. FactViewResearch. February 19, 2024. Retrieved June 28, 2024 from https://www.linkedin.com/pulse/personalized-nutrition-supplements-industry-innovations-jkx6f/.

Precision wellness and personalized supplements are a departure from the one-size-fits-all approach. Genetic testing has been used for this purpose, and digital platforms, including AI and data analytics, are also being used for personalized recommendations. In these scenarios, user behavior is analyzed and supplement recommendations are made accordingly.163Knyszewski J. Key Trends in the Global Supplements Market. Medium. Jan 10, 2024. Retrieved June 28, 2024 from https://medium.com/@thejeromeknyszewski/key-trends-in-the-global-supplements-market-4847e41ffb04

 

How Vitaquest Supports Brands in Leveraging Fall 2025 Supplement Opportunities

You must partner with Nutritional Supplement Contract Manufacturers possessing extensive experience and a proven track record.

Vitaquest is a Supplement Manufacturer that has provided supplement brands with exceptional supplement research and development, manufacturing, packaging design, powder and particle engineering services using fluid bed, oscillation, and roller compaction technologies, and fulfillment solutions for over 45 years.

Whether you’re a newcomer to the industry or aiming to diversify your product range, Vitaquest possesses the expertise, cutting-edge facilities, and solutions needed to swiftly and effectively turn your Fall 2025 supplement concepts into reality. Vitaquest offers a variety of dosage forms, including capsules, tablets, chewable tablets, oral disintegrating tablets (ODTs), effervescent tablets, and powders. Furthermore, you’ll receive an exceptional level of customer support.

As a dietary supplement manufacturer, Vitaquest brings expertise in both domestic and international regulatory standards, along with a strong commitment to sustainability. By sourcing sustainable ingredients and implementing eco-friendly manufacturing processes, we help brands enhance their market appeal. Our FDA cGMP compliance, along with third-party GMP certifications from NSF, USP, and others, assures brand owners and consumers that we meet the highest industry standards. Additionally, our certifications for Kosher, Halal, organic products, and FSSC 22000 for food safety further demonstrate our dedication to manufacturing excellence and regulatory compliance.

 

Concluding Thoughts

In this article, we examined the Fall 2025 supplement trends, including supplements for Immune-Boosting, Stress and Mood Support, Gut Health, Nutricosmetics, and Joint and Inflammation Support, as well as supplement trends for Evidence-Based Ingredients, Bioavailable and Enhanced Absorption Formulations, Multi-Functional Supplements, Proactive Health and Preventive Supplements, Personalized Supplements & Precision Wellness.

Are you ready to capitalize on the Fall 2025 dietary supplements market trends covered in this article? If so, call 800-526-9095 to speak with one of our knowledgeable sales executives or request a nutraceutical manufacturing price quote if you’ve already finalized your project requirements!

 

Frequently Asked Questions About the Fall 2025 Supplement Manufacturing Trends

Q: What are the top supplements for fall 2025?

The top supplements for fall 2025 include those for immune-boosting, stress and mood support, gut health, beauty-from-within, and joint and inflammation support. Additional top supplement considerations are those with evidence-based ingredients, bioavailable and enhanced absorption formulations, supplements with multiple benefits, preventive supplements, and personalized supplements.

Q: How do adaptogens work in stress management?

Adaptogens work with the adrenal glands and other organs to help the body adapt by normalizing physiological processes in times of increased stress. These adaptations result in broad-ranging beneficial effects. Common adaptogenic herbs include ginseng, ashwagandha, and Rhodiola.

Q: What is the future of collagen supplements?

The future of collagen supplements looks promising! The global collagen market was valued at $10.08 billion in 2022 and is projected to reach approximately $23.02 billion by 2032. Collagen remains one of the most popular nutraceuticals for skin health, with demand continuing to rise. Partnering with an experienced collagen supplement manufacturer can help brands capitalize on this growing market and develop high-quality products tailored to consumer needs.

Q: Why is gut health important in the fall?

People often start eating heavier foods during the fall. This includes those containing higher levels of total fat and saturated fat. These are more difficult to digest than other fats and can be hard on the digestive system. Consequently, the gut has to work harder in the fall. As a result, at this time there is a greater interest in the use of dietary supplements for gut health, including probiotics, fiber, and digestive enzymes.

Q: What makes a supplement “evidence-based”?

An evidence-based supplement is typically one that provides ingredients shown in human research to be effective for the purpose intended. Furthermore, those ingredients need to be present at the correct levels used in the research. Alternatively, an evidence-based supplement can also be one where a human study was conducted on the finished supplement itself.

 

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Lauren Samot, Commercial Innovation Leader - Vitaquest
Lauren
Samot, RD
Commercial Innovation Leader

With over 7 years at Vitaquest, Lauren Samot’s journey from Technical Services Associate to her current role as Commercial Innovation Leader exemplifies her dedication and growth. Leading the innovation team, she fuels business expansion through collaborative efforts across sales, product development, and operations. With a decade-long career in nutraceuticals, Lauren excels in manufacturing, raw materials, and product development. A Vitaquest Proud Champion Award recipient, she holds a B.S. in Nutritional Science with a minor in Public Health from Boston University and is an accomplished Registered Dietitian and member of the Academy of Nutrition and Dietetics.

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